Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites. (Q40880583)

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6 November 2019

title

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites (English)

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6 November 2019

1

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6 November 2019

author name string

Clarke DM

series ordinal

2

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6 November 2019

language of work or name

English

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publication date

1 June 2000

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Journal of Biological Chemistry

6 November 2019

published in

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6 November 2019

volume

275

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6 November 2019

issue

26

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6 November 2019

page(s)

19435-19438

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Biochemistry of multidrug resistance mediated by the multidrug transporter

6 November 2019

cites work

1 reference

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

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Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

21 January 2018

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Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

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The catalytic cycle of P-glycoprotein

21 January 2018

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Crystal structure of the ATP-binding subunit of an ABC transporter

21 January 2018

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Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

21 January 2018

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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

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P-glycoprotein. Associations between domains and between domains and molecular chaperones

21 January 2018

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The P-loop--a common motif in ATP- and GTP-binding proteins

21 January 2018

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Site-directed disulfide mapping of helices M4 and M6 in the Ca2+ binding domain of SERCA1a, the Ca2+ ATPase of fast twitch skeletal muscle sarcoplasmic reticulum

21 January 2018

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Activation of the human P-glycoprotein ATPase by trypsin

21 January 2018

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Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

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Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

21 January 2018

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Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

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Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.C000222200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10806188%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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