Identification of Residues in the Drug-binding Domain of Human P-glycoprotein (Q57976933)

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scientific article published in Journal of Biological Chemistry

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English	Identification of Residues in the Drug-binding Domain of Human P-glycoprotein	scientific article published in Journal of Biological Chemistry

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2 November 2019

Identification of residues in the drug-binding domain of human P-glycoprotein. Analysis of transmembrane segment 11 by cysteine-scanning mutagenesis and inhibition by dibromobimane (English)

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Europe PubMed Central

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2 November 2019

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ChEBI release 2020-05-28

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2 November 2019

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D M Clarke

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2 November 2019

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1 December 1999

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2 November 2019

Journal of Biological Chemistry

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2 November 2019

274

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2 November 2019

50

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2 November 2019

35388-35392

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2 November 2019

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Clinical multidrug resistance in cancer: a multifactorial problem

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Diagnosis and reversal of multidrug resistance in paediatric cancers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Expression of the human multidrug transporter in insect cells by a recombinant baculovirus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Drug-stimulated ATPase activity of a deletion mutant of the human multidrug-resistance protein (MDR1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Alteration of Substrate Specificity by Mutations at the His61Position in Predicted Transmembrane Domain 1 of Human MDR1/P-Glycoprotein†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Both P-glycoprotein nucleotide-binding sites are catalytically active

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Mutational analysis of the P-glycoprotein first intracellular loop and flanking transmembrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Functional dissection of P-glycoprotein nucleotide-binding domains in chimeric and mutant proteins. Modulation of drug resistance profiles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.35388

21 January 2018

Identifiers

10.1074/JBC.274.50.35388

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10585407%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10585407%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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