A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. (Q40883167)

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English	A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line.	scientific article

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6 November 2019

A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line (English)

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6 November 2019

hepatocellular carcinoma

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Christoph Handschin

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6 November 2019

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U A Meyer

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6 November 2019

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1 May 2000

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6 November 2019

Journal of Biological Chemistry

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6 November 2019

275

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6 November 2019

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6 November 2019

13362-13369

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6 November 2019

Enzyme induction in the cytochrome P-450 system

1 reference

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Xenobiotic-inducible transcription of cytochrome P450 genes.

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Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers

1 reference

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Phenobarbital induction of cytochrome P-450 gene expression

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Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

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A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids

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Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif

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Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

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Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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21 January 2018

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

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MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

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Base preferences for DNA binding by the bHLH-Zip protein USF: effects of MgCl2 on specificity and comparison with binding of Myc family members.

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Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

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HNF1, a homeoprotein member of the hepatic transcription regulatory network

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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Mechanisms of transactivation by retinoic acid receptors

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Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases

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Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

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Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers

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21 January 2018

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

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21 January 2018

Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

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Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

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Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation

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Involvement of synthesis and phosphorylation of nuclear protein factors that bind to the positive cis-acting element in the transcriptional activation of the CYP2B1/B2 gene by phenobarbitone in vivo

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Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37).

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Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

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P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness

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Analysis of a phenobarbital-responsive enhancer sequence located in the 5' flanking region of the chicken CYP2H1 gene: identification and characterization of functional protein-binding sites

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Liver-enriched transcription factors, HNF-1, HNF-3, and C/EBP, are major contributors to the strong activity of the chicken CYP2H1 promoter in chick embryo hepatocytes

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10.1074/JBC.275.18.13362

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10788445%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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6 November 2019

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