The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes (Q40884595)

24 September 2017

The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes (English)

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24 September 2017

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5

J M Olefsky

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24 September 2017

N Nakashima

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24 September 2017

P M Sharma

series ordinal

2

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24 September 2017

T Imamura

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3

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24 September 2017

R Bookstein

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4

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24 September 2017

language of work or name

English

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publication date

1 April 2000

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Journal of Biological Chemistry

24 September 2017

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24 September 2017

275

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24 September 2017

17

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24 September 2017

12889-12895

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New frontiers in insulin receptor substrate signaling.

24 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Role of IRS-2 in insulin and cytokine signalling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Signalling through the lipid products of phosphoinositide-3-OH kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Facilitative glucose transporters

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

The insulin signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Inositol lipid 5-phosphatases--traffic signals and signal traffic.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Purification of a type 5 recombinant adenovirus encoding human p53 by column chromatography

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Analytical anion-exchange HPLC of recombinant type-5 adenoviral particles

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Activation of phosphatidylinositol 3-kinase by insulin

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.17.12889

21 January 2018

Identifiers

DOI

10.1074/JBC.275.17.12889

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24 September 2017

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