The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. (Q40894474)

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4 November 2019

title

The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway (English)

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4 November 2019

5

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4 November 2019

author name string

North S

1

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4 November 2019

El-Ghissassi F

2

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4 November 2019

Pluquet O

3

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4 November 2019

Verhaegh G

4

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4 November 2019

language of work or name

English

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publication date

1 February 2000

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4 November 2019

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4 November 2019

volume

19

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page(s)

1206-1214

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issue

9

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203413

4 November 2019

exact match

0 references

cites work

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

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p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage.

21 January 2018

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The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine (Ethyol).

21 January 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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Hprt mutations in human T-lymphocytes reflect radioprotective effects of the aminothiol, WR-1065.

21 January 2018

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Expression and stability of p53 protein in normal human mammary epithelial cells

21 January 2018

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Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells

21 January 2018

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Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

21 January 2018

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The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells.

21 January 2018

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Influence of single and multiple doses of amifostine on the efficacy and the pharmacokinetics of carboplatin in mice

21 January 2018

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

21 January 2018

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Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine.

21 January 2018

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Multisite phosphorylation and the integration of stress signals at p53.

21 January 2018

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Mammalian cell polyamine homeostasis is altered by the radioprotector WR1065.

21 January 2018

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A model for p53-induced apoptosis

21 January 2018

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Role of cysteine residues in regulation of p53 function

21 January 2018

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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

21 January 2018

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Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065

21 January 2018

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Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

21 January 2018

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Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

21 January 2018

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Competition for polyamine uptake into rat lung slices by WR2721 and analogues

21 January 2018

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Binding of Polyamines to an Autonomous Domain of the Regulatory Subunit of Protein Kinase CK2 Induces a Conformational Change in the Holoenzyme

21 January 2018

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Inhibition of topoisomerase II alpha activity in CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065).

21 January 2018

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7 January 2021

Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

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7 January 2021

Chemical protection and cell-cycle effects on radiation-induced mutagenesis

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7 January 2021

Pharmacokinetics of cisplatin with and without amifostine in tumour-bearing nude mice

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7 January 2021

Amifostine stimulates formation of multipotent and erythroid bone marrow progenitors

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7 January 2021

Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells

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7 January 2021

Effect of hydroxyl radical scavenging capacity on clustering of DNA damage.

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7 January 2021

Amifostine, cisplatin, and vinblastine in metastatic non-small-cell lung cancer: a report of high response rates and prolonged survival

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7 January 2021

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203413

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713709%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 November 2019

0 references

1 reference