NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity (Q40899393)

24 September 2017

NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity (English)

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24 September 2017

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J J Pink

1

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24 September 2017

S M Planchon

2

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24 September 2017

C Tagliarino

3

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24 September 2017

M E Varnes

4

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24 September 2017

D Siegel

5

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24 September 2017

D A Boothman

6

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24 September 2017

language of work or name

English

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publication date

1 February 2000

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Journal of Biological Chemistry

24 September 2017

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24 September 2017

275

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24 September 2017

5416-5424

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24 September 2017

8

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beta-Lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-alpha. Inhibitory effect, thiol dependence and specificity

24 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

β-lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by Sarcoma 180 ascites tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Isolation of x-ray-inducible transcripts from radioresistant human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

NAD(P)H:quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

DT-diaphorase and cancer chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Sequence-selective alkylation and cross-linking induced by mitomycin C upon activation by DT-diaphorase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Studies on the reaction mechanism of DT diaphorase. Action of dead-end inhibitors and effects of phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

The role of reductive and oxidative metabolism in the toxicity of mitoxantrone, adriamycin and menadione in human liver derived Hep G2 hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Irreversible loss of the oestrogen receptor in T47D breast cancer cells following prolonged oestrogen deprivation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

A simple, rapid, and sensitive DNA assay procedure

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Studies on the reaction mechanism of DT diaphorase. Intermediary plateau and trough regions in the initial velocity vs substrate concentration curves

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

7 Purification and properties of NADPH-Cytochrome P-450 reductase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

A note on the inhibition of DT-diaphorase by dicoumarol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Nuclear accumulation of p53 in response to treatment with DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Inhibition of radiation-induced neoplastic transformation by beta-lapachone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Calpain and calpastatin regulate neutrophil apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

On the mechanism of one-electron reduction of quinones by microsomal flavin enzymes: the kinetic analysis between cytochrome B5 and menadione

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in β-lapachone-treated Trypanosoma cruzi epimastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

DNA damage-inducible transcripts in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.275.8.5416

21 January 2018

Identifiers

DOI

10.1074/JBC.275.8.5416

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release_zyh5lwoeqrbmjpu76q3kbjrfni

24 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/zyh5lwoeqrbmjpu76q3kbjrfni

mapped directly with Wikidata item

24 November 2022

based on heuristic

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