Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. (Q40906953)

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English	Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.	scientific article

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scholarly article

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Europe PubMed Central

24 September 2017

Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease (English)

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12 May 2020

apoptotic process

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Sebastian Kügler

3

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12 May 2020

Jörg B. Schulz

14

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12 May 2020

author name string

O Eberhardt

1

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12 May 2020

R V Coelln

2

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12 May 2020

J Lindenau

4

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12 May 2020

S Rathke-Hartlieb

5

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12 May 2020

E Gerhardt

6

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12 May 2020

S Haid

7

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12 May 2020

S Isenmann

8

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12 May 2020

C Gravel

9

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12 May 2020

A Srinivasan

10

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12 May 2020

M Bahr

11

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12 May 2020

M Weller

12

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12 May 2020

J Dichgans

13

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12 May 2020

language of work or name

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publication date

1 December 2000

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24 September 2017

Journal of Neuroscience

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12 May 2020

20

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12 May 2020

24

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12 May 2020

9126-9134

1 reference

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12 May 2020

An adenovirus vector for gene transfer into neurons and glia in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potassium deprivation-induced apoptosis of cerebellar granule neurons: a sequential requirement for new mRNA and protein synthesis, ICE-like protease activity, and reactive oxygen species.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death and apoptosis regulating proteins in Parkinson's disease--a cautionary note.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IAP family proteins--suppressors of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective and neurorestorative properties of GDNF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Apoptotic" biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase inhibition reduces apoptosis and increases survival of nigral transplants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic neurons protected from degeneration by GDNF gene therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New animal models for Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional recovery in parkinsonian monkeys treated with GDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor exerts neurotrophic effects on dopaminergic neurons in vitro and promotes their survival and regrowth after damage by 1-methyl-4-phenylpyridinium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of free radicals in excitotoxicity in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated transduction with human glial cell line-derived neurotrophic factor gene prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopamine depletion in striatum of mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The search for synergy: a critical review from a response surface perspective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein from chromaffin granules promotes survival of mesencephalic dopaminergic neurons by an EGF-receptor ligand-mediated mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspases as treatment targets in stroke and neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histochemical detection of apoptosis in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction in movement disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.20-24-09126.2000

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6773033&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6773033&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6773033&resulttype=core&format=json

12 May 2020

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