The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2. (Q40914048)

24 September 2017

The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2. (English)

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24 September 2017

H Wada

1

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24 September 2017

E T Yeh

series ordinal

2

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24 September 2017

T Kamitani

series ordinal

3

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24 September 2017

language of work or name

English

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publication date

1 December 1999

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Journal of Biological Chemistry

24 September 2017

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24 September 2017

274

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24 September 2017

36025-36029

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24 September 2017

50

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Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer

24 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Inhibition of transcription elongation by the VHL tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Identification of NEDD8-conjugation site in human cullin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Cloning of a cDNA which encodes a novel ubiquitin-like protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Characterization of a second member of the sentrin family of ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Covalent modification of PML by the sentrin family of ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Cleavage of the C-terminus of NEDD8 by UCH-L3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

A new NEDD8-ligating system for cullin-4A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Many vessels, faulty gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

There's the rub: a novel ubiquitin-like modification linked to cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

Activation-induced aggregation and processing of the human Fas antigen. Detection with cytoplasmic domain-specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.50.36025

21 January 2018

Identifiers

DOI

10.1074/JBC.274.50.36025

1 reference

24 September 2017

1 reference