Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha (Q40924424)

24 September 2017

title

Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha (English)

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24 September 2017

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Shigetsugu Hatakeyama

2

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24 September 2017

K Hattori

1

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24 September 2017

M Shirane

3

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24 September 2017

M Matsumoto

4

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24 September 2017

K Nakayama

5

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24 September 2017

language of work or name

English

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publication date

1 October 1999

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

274

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24 September 2017

issue

42

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24 September 2017

page(s)

29641-29647

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The ubiquitin system for protein degradation

24 September 2017

cites work

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

21 January 2018

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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Identification and characterization of an IkappaB kinase

21 January 2018

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

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Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

21 January 2018

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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IKAP is a scaffold protein of the IkappaB kinase complex

21 January 2018

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

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Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

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Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

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Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

21 January 2018

1 reference

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 January 2018

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Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

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Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

21 January 2018

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

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HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

21 January 2018

1 reference

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Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

21 January 2018

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

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beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation

21 January 2018

1 reference

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IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.

21 January 2018

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Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

21 January 2018

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A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

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Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

21 January 2018

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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

21 January 2018

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

21 January 2018

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Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.

21 January 2018

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Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase

21 January 2018

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

21 January 2018

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Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

21 January 2018

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

Frequent beta-catenin abnormalities in bone and soft-tissue tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

A common human skin tumour is caused by activating mutations in beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

Characterization of the cullin and F-box protein partner Skp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

NF-kappa B: a lesson in family values

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

In vivo and in vitro recruitment of an IkappaBalpha-ubiquitin ligase to IkappaBalpha phosphorylated by IKK, leading to ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.42.29641

21 January 2018

Identifiers

DOI

10.1074/JBC.274.42.29641

1 reference

24 September 2017

1 reference