Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. (Q40927249)

24 September 2017

title

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. (English)

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24 September 2017

main subject

protein ubiquitination

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based on heuristic

inferred from title

author

Shigetsugu Hatakeyama

2

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24 September 2017

Shirane M

1

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24 September 2017

Hattori K

3

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24 September 2017

Nakayama K

4

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24 September 2017

Nakayama K

5

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24 September 2017

language of work or name

English

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publication date

1 October 1999

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Journal of Biological Chemistry

24 September 2017

published in

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24 September 2017

volume

274

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24 September 2017

issue

40

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24 September 2017

page(s)

28169-28174

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Signal transduction through NF-kappa B.

24 September 2017

cites work

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

21 January 2018

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21 January 2018

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21 January 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

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Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 January 2018

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HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

21 January 2018

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Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.

21 January 2018

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

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A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

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Interleukin-1-induced nuclear factor-kappaB-IkappaBalpha autoregulatory feedback loop in hepatocytes. A role for protein kinase calpha in post-transcriptional regulation of ikappabalpha resynthesis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.40.28169

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24 September 2017

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