Interleukin-12 an integral cytokine in the immune response (Q40965432)

25 September 2017

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title

Interleukin-12 an integral cytokine in the immune response (English)

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25 September 2017

Stern AS

1

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25 September 2017

Magram J

series ordinal

2

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25 September 2017

Presky DH

series ordinal

3

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25 September 2017

language of work or name

English

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publication date

1 January 1996

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25 September 2017

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25 September 2017

58

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25 September 2017

8

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25 September 2017

639-654

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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

25 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Antitumor and antimetastatic activity of interleukin 12 against murine tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Recombinant interleukin 12 cures mice infected with Leishmania major

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Cytokine treatment of central nervous system infection: efficacy of interleukin-12 alone and synergy with conventional antifungal therapy in experimental cryptococcosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Molecular characterization of interleukin 12

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Structure-function analysis of the p35 subunit of mouse interleukin 12.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Identification and induction of human keratinocyte-derived IL-12

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12 production by human polymorphonuclear leukocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Preferential expression of interleukin-12 or interleukin-4 by murine bone marrow mast cells derived in mast cell growth factor or interleukin-3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 at the site of disease in tuberculosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Lymphocyte responses and cytokines

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Differential effects of interleukin-12 on the development of naive mouse CD4+ T cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factor-beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 induction of interferon gamma-dependent protection against malaria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 is effective treatment for an established systemic intracellular infection: experimental visceral leishmaniasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Transforming growth factor-beta inhibits interleukin-12-induced production of interferon-gamma by natural killer cells: a role for transforming growth factor-beta in the regulation of T cell-independent resistance to Toxoplasma gondii.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Gene expression and secretion of cytokines and cytokine receptors from highly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12 but not interferon-γ production correlates with induction of T helper type-1 phenotype in murine candidiasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Cytokine patterns at the site of mycobacterial infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

The Th1-Th2 hypothesis of HIV infection: new insights

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Impaired interleukin 12 production in human immunodeficiency virus-infected patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Type 1/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Receptor-induced death in human natural killer cells: involvement of CD16.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Regulation of human cytolytic lymphocyte responses by interleukin-12

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12, interferon gamma, and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Multiple effects on peripheral hematology following administration of recombinant human interleukin 12 to nonhuman primates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: implications for the immunotherapy of cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0024-3205%2896%2980003-8

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7 January 2021

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Identifiers

DOI

10.1016/S0024-3205(96)80003-8

1 reference

25 September 2017

1 reference