Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain (Q40970925)

25 September 2017

Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain (English)

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25 September 2017

David William Andrews

4

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25 September 2017

Froesch BA

1

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25 September 2017

Aimé-Sempé C

2

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25 September 2017

Leber B

3

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25 September 2017

Reed JC

5

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25 September 2017

language of work or name

English

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publication date

1 March 1999

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Journal of Biological Chemistry

25 September 2017

7

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based on heuristic

inferred from page(s)

published in

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25 September 2017

274

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25 September 2017

10

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25 September 2017

6469-6475

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Bcl-2 and the regulation of programmed cell death

25 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

The proto-oncogene Bcl-2 and its role in regulating apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Double identity for proteins of the Bcl-2 family

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Mitochondria and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Bcl-2 associates with the ras-related protein R-ras p23

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

21 January 2018

p53: puzzle and paradigm

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

p53 function and dysfunction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Apoptosis in cancer therapy: crossing the threshold

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Bcl-2 blocks p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Bcl-2 inhibits p53 nuclear import following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Eukaryotic expression vectors for the analysis of mutant proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Two cellular proteins that bind to wild-type but not mutant p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Calcium and S100B regulation of p53-dependent cell growth arrest and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Involvement of the bcl-2 gene in human follicular lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Checkpoints of dueling dimers foil death wishes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

p21(WAF1/CIP1) response to genotoxic agents in wild-type TP53 expressing breast primary tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

Effect of 1,25 dihydroxyvitamin D3 and calcium on growth and differentiation and on c-fos and p53 gene expression in normal human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.10.6469

21 January 2018

Identifiers

DOI

10.1074/JBC.274.10.6469

1 reference

25 September 2017

1 reference