Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway (Q40973684)

25 September 2017

Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway (English)

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25 September 2017

Law BK

1

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25 September 2017

Nørgaard P

2

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25 September 2017

Gnudi L

3

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25 September 2017

Kahn BB

4

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25 September 2017

Poulson HS

5

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25 September 2017

Moses HL

6

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25 September 2017

language of work or name

English

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publication date

1 February 1999

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Journal of Biological Chemistry

25 September 2017

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25 September 2017

274

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25 September 2017

8

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25 September 2017

4743-4748

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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

25 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Signal transduction from multiple Ras effectors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

PI3K: downstream AKTion blocks apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Identification and characterization of a mitogen-activated S6 kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

TOR controls translation initiation and early G1 progression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Structural and functional analysis of pp70S6k

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

p70s6k function is essential for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.8.4743

21 January 2018

Identifiers

DOI

10.1074/JBC.274.8.4743

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release_s5n46tpvofgbxaocapotkuulbq

25 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/s5n46tpvofgbxaocapotkuulbq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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