gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein (Q40993775)

25 September 2017

title

gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein (English)

1 reference

25 September 2017

main subject

transmembrane protein

0 references

endoplasmic reticulum

0 references

author name string

W L Bunnell

series ordinal

1

1 reference

25 September 2017

H V Pham

series ordinal

2

1 reference

25 September 2017

C G Glabe

series ordinal

3

1 reference

25 September 2017

language of work or name

English

0 references

publication date

1 November 1998

1 reference

Journal of Biological Chemistry

25 September 2017

published in

1 reference

25 September 2017

volume

273

1 reference

25 September 2017

issue

48

1 reference

25 September 2017

page(s)

31947-31955

1 reference

Intracellular degradation of unassembled asialoglycoprotein receptor subunits: a pre-Golgi, nonlysosomal endoproteolytic cleavage

25 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

The structure of an antigenic determinant in a protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

A permeabilized cell system identifies the endoplasmic reticulum as a site of protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Cysteine proteinase inhibitors and ras gene products share the same biological activities including transforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inducing activity toward PC12 rat pheochromocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Inhibition of the calpain-mediated proteolysis of protein kinase C enhances lytic activity in human NK cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Degradation of CFTR by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Protein topology of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

A two-site model for ApoB degradation in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

Long Amyloid .beta.-Protein Secreted from Wild-Type Human Neuroblastoma IMR-32 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.48.31947

21 January 2018

Identifiers

DOI

10.1074/JBC.273.48.31947

1 reference

25 September 2017

1 reference