High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds (Q41019428)

25 September 2017

High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds (English)

1 reference

25 September 2017

Tarbit MH

1

1 reference

PubMed ID

9691080

25 September 2017

Berman J

series ordinal

2

1 reference

PubMed ID

9691080

25 September 2017

language of work or name

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1 June 1998

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Current Opinion in Chemical Biology

25 September 2017

1 reference

25 September 2017

2

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25 September 2017

3

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25 September 2017

411-416

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Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective

25 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Lead development: validation and application of high throughput screening for determination of pharmacokinetic parameters for enzyme inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Distribution coefficient, a convenient term for the relation of predictable physico-chemical properties to metabolic processes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography-atmospheric pressure ionization tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Simultaneous pharmacokinetic screening of a mixture of compounds in the dog using API LC/MS/MS analysis for increased throughput

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Intestinal absorption screening of mixtures from combinatorial libraries in the Caco-2 model

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Estimation and correlation of drug water solubility with pharmacological parameters required for biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Correlation of drug absorption with molecular surface properties

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Expression of drug-metabolizing enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

Quantitative structure-activity relationships in substrates, inducers, and inhibitors of cytochrome P4501 (CYP1).

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2898%2980017-3

7 January 2021

10.1016/S1367-5931(98)80017-3

Identifiers

DOI

1 reference

25 September 2017

1 reference

PubMed ID

9691080