Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes. (Q41028627)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651339%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes (English)

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12 November 2019

1 reference

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5

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12 November 2019

Yumi Imai

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2

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12 November 2019

author name string

K I Rother

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1

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12 November 2019

M Caruso

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651339%20AND%20SRC:MED&resulttype=core&format=json

3

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12 November 2019

F Beguinot

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651339%20AND%20SRC:MED&resulttype=core&format=json

4

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12 November 2019

D Accili

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6

1 reference

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12 November 2019

language of work or name

English

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publication date

1 July 1998

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Journal of Biological Chemistry

12 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651339%20AND%20SRC:MED&resulttype=core&format=json

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651339%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

volume

273

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12 November 2019

page(s)

17491-17497

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9651339%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

issue

28

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

12 November 2019

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IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

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Correction of diabetic alterations by glucokinase.

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In skeletal muscle, glucose storage and oxidation are differentially impaired by the IR1152 mutant receptor.

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Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

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IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

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Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes.

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Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin

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Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells

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Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells

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Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

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