Serpin family E member 1 (Q410485)

serpin family

1 reference

stated in

Serpin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serpin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

peptidase inhibitor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

5 references

8 April 2019

Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

3 references

8 April 2019

PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Binding of PAI-1 to endothelial cells stimulated by thymosin beta4 and modulation of their fibrinolytic potential

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

signaling receptor binding

IPI

1 reference

8 April 2019

Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

serine-type endopeptidase inhibitor activity

IPI

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

serine-type endopeptidase inhibitor activity

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

serine-type endopeptidase inhibitor activity

IBA

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

platelet alpha granule lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

1 January 2018

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

collagen-containing extracellular matrix

IBA

3 references

8 April 2019

Plasminogen activator inhibitor-1 deposition in the extracellular matrix of cultured human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of endothelial cell apoptotic process

HDA

biological process

1 reference

8 April 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of receptor-mediated endocytosis

1 reference

8 April 2019

Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of peptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of fibrinolysis

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of inflammatory response

1 reference

8 April 2019

Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of plasminogen activation

IGI

3 references

8 April 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Anticoagulant and antithrombotic properties of platelet protease nexin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

8 April 2019

Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of smooth muscle cell-matrix adhesion

1 reference

8 April 2019

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of blood coagulation

1 reference

8 April 2019

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of vascular wound healing

IC

1 reference

8 April 2019

Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

regulation of signaling receptor activity

IGI

1 reference

8 April 2019

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of smooth muscle cell migration

1 reference

8 April 2019

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of monocyte chemotaxis

1 reference

8 April 2019

Plasminogen activator inhibitor-1 promotes inflammatory process induced by cigarette smoke extraction or lipopolysaccharides in alveolar epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

platelet degranulation

1 reference

8 April 2019

extracellular matrix organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of angiogenesis

1 reference

8 April 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of cell migration

1 reference

8 April 2019

Autocrine regulation of human preadipocyte migration by plasminogen activator inhibitor-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of blood coagulation

1 reference

8 April 2019

Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

defense response to Gram-negative bacterium

1 reference

8 April 2019

Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

IGI

1 reference

8 April 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

1 reference

8 April 2019

Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of interleukin-8 production

IEP

1 reference

8 April 2019

Plasminogen activator inhibitor-1 promotes inflammatory process induced by cigarette smoke extraction or lipopolysaccharides in alveolar epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of wound healing

1 reference

8 April 2019

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

cellular response to lipopolysaccharide

IC

1 reference

8 April 2019

Plasminogen activator inhibitor-1 promotes inflammatory process induced by cigarette smoke extraction or lipopolysaccharides in alveolar epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of cell adhesion mediated by integrin

1 reference

8 April 2019

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of endopeptidase activity

1 reference

1 January 2018

Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties

http://www.ebi.ac.uk/QuickGO/annotations?protein=P05121&geneProductId=UniProtKB:P05121

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of leukotriene production involved in inflammatory response

1 reference

8 April 2019

Plasminogen activator inhibitor-1 promotes inflammatory process induced by cigarette smoke extraction or lipopolysaccharides in alveolar epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

replicative senescence

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

1 reference

8 April 2019

Recombinant Human Plasminogen Activator Inhibitor-1 Accelerates Odontoblastic Differentiation of Human Stem Cells from Apical Papilla

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

positive regulation of odontoblast differentiation

1 reference

8 April 2019

Recombinant Human Plasminogen Activator Inhibitor-1 Accelerates Odontoblastic Differentiation of Human Stem Cells from Apical Papilla

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05121

negative regulation of endopeptidase activity

PBB GE SERPINE1 202627 s at fs.png
732 × 530; 10 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P05121

1 reference

1 reference

Serpin, conserved site

1 reference

stated in

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers

MeSH descriptor ID

D017395

subject named as

Plasminogen Activator Inhibitor 1

0 references

0 references

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016

1 reference

2 August 2016