Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease (Q41146384)

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scientific article published on 22 September 2016

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English	Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease	scientific article published on 22 September 2016

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scholarly article

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Europe PubMed Central

27 September 2017

Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease (English)

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27 September 2017

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Joseph M. Wallace

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1 June 2020

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Toshifumi Sugatani

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Olga A Agapova

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Yifu Fang

3

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Alycia G Berman

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Hartmut H Malluche

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1 June 2020

Marie-Claude Faugere

7

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William Smith

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Victoria Sung

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Keith A Hruska

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publication date

22 September 2016

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Kidney International

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91

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86-95

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1 June 2020

1

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1 June 2020

Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Type 2 diabetes and the skeleton: new insights into sweet bones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Determinants of bone strength and quality in diabetes mellitus in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy

1 reference

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27 September 2017

CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder

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27 September 2017

Role of TGF-β in a mouse model of high turnover renal osteodystrophy

1 reference

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27 September 2017

Early chronic kidney disease-mineral bone disorder stimulates vascular calcification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion

1 reference

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27 September 2017

Early skeletal and biochemical alterations in pediatric chronic kidney disease

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27 September 2017

Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids

1 reference

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27 September 2017

Klotho deficiency causes vascular calcification in chronic kidney disease

1 reference

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27 September 2017

TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling

1 reference

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27 September 2017

ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD).

1 reference

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27 September 2017

Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease

1 reference

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27 September 2017

KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

A soluble activin type IIA receptor induces bone formation and improves skeletal integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)

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27 September 2017

Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

A role for Wnt-4 in renal fibrosis

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27 September 2017

Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

27 September 2017

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

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27 September 2017

Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.

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19 August 2018

Genomewide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

19 August 2018

Disturbances of Wnt/β-catenin pathway and energy metabolism in early CKD: effect of phosphate binders

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

19 August 2018

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

19 August 2018

The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.

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19 August 2018

A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys

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19 August 2018

Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model

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19 August 2018

Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5530394

19 August 2018

BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure.

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19 August 2018

Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy

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19 August 2018

Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27666759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27666759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27666759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning

1 reference

https://pubmed.ncbi.nlm.nih.gov/27666759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/27666759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.KINT.2016.07.039

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27666759%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27666759%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27666759%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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