Interleukin 1 beta (Q411529)

Cytokine IL1/FGF

1 reference

Transporter Classification Database ID

interleukin-1 family

1 reference

1.A.109.1.2

hierarchical database ID heuristic

2 October 2019

based on heuristic

Interleukin-1 propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Interleukin-1 conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein domain specific binding

1 reference

8 April 2019

The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

interleukin-1 receptor binding

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

cytokine activity

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

cytokine activity

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

integrin binding

1 reference

8 April 2019

Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

protein binding

1 reference

8 April 2019

PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

5 references

8 April 2019

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

8 April 2019

Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

lysosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

extracellular exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

secretory granule

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

extracellular space

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

5 references

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

extracellular space

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of protein phosphorylation

biological process

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

smooth muscle adaptation

1 reference

8 April 2019

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of calcidiol 1-monooxygenase activity

cellular response to mechanical stimulus

IEP

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of interleukin-8 production

IEP

1 reference

8 April 2019

Induction of chemokine expression by adiponectin in vitro is isoform dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of mitotic nuclear division

1 reference

8 April 2019

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

response to carbohydrate

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

embryo implantation

1 reference

8 April 2019

Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

negative regulation of cell population proliferation

1 reference

8 April 2019

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

apoptotic process

1 reference

8 April 2019

Cytokine-induced neutrophil-mediated injury of human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

cellular response to organic substance

1 reference

8 April 2019

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of phagocytosis

1 reference

8 April 2019

Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

regulation of insulin secretion

1 reference

8 April 2019

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

neutrophil chemotaxis

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of protein export from nucleus

1 reference

8 April 2019

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of myosin light chain kinase activity

1 reference

8 April 2019

Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of T cell proliferation

1 reference

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

inflammatory response

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

sequestering of triglyceride

1 reference

8 April 2019

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

hyaluronan biosynthetic process

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of heterotypic cell-cell adhesion

cellular response to organic cyclic compound

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

response to lipopolysaccharide

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01584&geneProductId=UniProtKB:P01584

positive regulation of NF-kappaB transcription factor activity

positive regulation of granulocyte macrophage colony-stimulating factor production

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

ectopic germ cell programmed cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

leukocyte migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of cell adhesion molecule production

1 reference

8 April 2019

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

response to ATP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

monocyte aggregation

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

protein kinase B signaling

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

cell-cell signaling

1 reference

8 April 2019

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of monocyte chemotactic protein-1 production

1 reference

8 April 2019

Induction of chemokine expression by adiponectin in vitro is isoform dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of membrane protein ectodomain proteolysis

1 reference

8 April 2019

The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of interferon-gamma production

MAPK cascade

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of histone acetylation

1 reference

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of gene expression

4 references

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

The microRNA-29 family in cartilage homeostasis and osteoarthritis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

interleukin-1 beta production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of T cell mediated immunity

1 reference

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

positive regulation of vascular endothelial growth factor production

3 references

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

23 May 2017

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

1 reference

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

negative regulation of lipid catabolic process

1 reference

8 April 2019

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

regulation of establishment of endothelial barrier

1 reference

8 April 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

positive regulation of transcription by RNA polymerase II

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

cytokine-mediated signaling pathway

1 reference

23 May 2017

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

regulation of defense response to virus by host

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of JNK cascade

1 reference

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

fever generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

positive regulation of cell population proliferation

1 reference

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of vascular endothelial growth factor production

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of gene expression

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

The microRNA-29 family in cartilage homeostasis and osteoarthritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of epithelial to mesenchymal transition

1 reference

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

3 references

8 April 2019

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of cell migration

1 reference

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

interleukin-6 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of interleukin-6 production

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of angiogenesis

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of JNK cascade

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

regulation of neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

negative regulation of neurogenesis

ISS

1 reference

8 April 2019

Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

regulation of nitric-oxide synthase activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of glial cell proliferation

1 reference

8 April 2019

Effects of Interleukin-1 and Tumor Necrosis Factor-α on Astrocytes, Microglia, Oligodendrocytes, and Glial Precursors in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

interleukin-1-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

1 reference

8 April 2019

cellular response to lipopolysaccharide

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of neuroinflammatory response

1 reference

8 April 2019

Role of TNF in mast cell neuroinflammation and pain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of T-helper 1 cell cytokine production

1 reference

8 April 2019

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of gene expression

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes.

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

The microRNA-29 family in cartilage homeostasis and osteoarthritis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of prostaglandin biosynthetic process

1 reference

8 April 2019

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of interleukin-6 production

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of complement activation

1 reference

8 April 2019

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of inflammatory response

1 reference

8 April 2019

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

response to interleukin-1

1 reference

8 April 2019

MiR-204 enhances the progression of osteoarthritis by suppressing the production of IL-1β.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

positive regulation of RNA biosynthetic process

1 reference

8 April 2019

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

imported from Wikimedia project

Gene Atlas image

PBB GE IL1B 39402 at.png
255 × 135; 532 bytes

1 reference

English Wikipedia

exact match

http://purl.uniprot.org/uniprot/P01584

1 reference

Interleukin-1 conserved site

Identifiers.org

has part(s)

1 reference

Interleukin-1 propeptide

1 reference

Guide to Pharmacology Ligand ID

Identifiers

ChEMBL ID

CHEMBL2074848

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

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1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

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1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

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4 August 2016

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4 August 2016

1 reference

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4 August 2016

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4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

Transporter Classification Database ID

English

1.A.109.1.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database