The role of interleukin-1 in the pathogenesis of IDDM. (Q41172449)

27 September 2017

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title

The role of interleukin-1 in the pathogenesis of IDDM. (English)

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27 September 2017

Thomas Mandrup-Poulsen

object named as

T Mandrup-Poulsen

series ordinal

1

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publication date

1 September 1996

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27 September 2017

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27 September 2017

39

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27 September 2017

9

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27 September 2017

1005-1029

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Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM

27 September 2017

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12 December 2020

Analysis of IL-2 receptor positive CD8(+)-T-lymphocytes grown from islets of NOD mice

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12 December 2020

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats.

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12 December 2020

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice

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12 December 2020

Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation

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12 December 2020

Interleukin 1 beta increases the cytosolic free sodium concentration in isolated rat islets of Langerhans

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12 December 2020

Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

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12 December 2020

Interleukin-1 beta depletes insulin messenger ribonucleic acid and increases the heat shock protein hsp70 in mouse pancreatic islets without impairing the glucose metabolism

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12 December 2020

Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.

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12 December 2020

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes

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12 December 2020

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

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12 December 2020

Effects of cytokines on rat insulinoma INS-1 cells

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12 December 2020

Interleukin-1β regulation of islet and thyroid autoimmunity in the BB rat

1 reference

12 December 2020

Biochemical and Molecular Actions of Interleukin-1 on Pancreatic β-Cells

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12 December 2020

Effects of free radical scavengers on cytokine actions on islet cells

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12 December 2020

Natural killer cell depletion and diabetes mellitus in the BB/Wor rat (revisited)

1 reference

12 December 2020

Role of CD8+ T cells in murine experimental allergic encephalomyelitis

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12 December 2020

Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

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12 December 2020

Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase

1 reference

12 December 2020

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice

1 reference

12 December 2020

Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts

1 reference

12 December 2020

Interleukin-1 beta inhibition of insulin release in rat pancreatic islets: possible involvement of G-proteins in the signal transduction pathway

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12 December 2020

Decreased cell replication and polyamine content in insulin-producing cells after exposure to human interleukin 1 beta.

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12 December 2020

Effector functions of macrophages.

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12 December 2020

Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans

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12 December 2020

Endogenous TNF production differs between high and low diabetes incidence non-obese diabetic (NOD) mice

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12 December 2020

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide

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12 December 2020

Systemic elimination of macrophages using liposomes does not prevent the induction of type I diabetes

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12 December 2020

Interleukin-1 beta (IL-1) does not reduce the diabetes incidence in diabetes-prone BB rats

1 reference

12 December 2020

Cytokines in sera from insulin-dependent diabetic patients at diagnosis

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12 December 2020

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

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12 December 2020

Oxygen radical production is increased in macrophages from diabetes prone BB rats.

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12 December 2020

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33.

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12 December 2020

Transgenic mice in the study of cytokine function

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12 December 2020

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice

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12 December 2020

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin-2 in islet beta cells

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12 December 2020

Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages

1 reference

12 December 2020

Murine macrophages and pancreatic beta cells. Chemotactic properties of insulin and beta-cytostatic action of interleukin 1.

1 reference

12 December 2020

Cytokines cause functional and structural damage to isolated islets of Langerhans

1 reference

12 December 2020

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

1 reference

12 December 2020

Low levels of mumps virus antigen induced interferon-alpha production in insulin-dependent diabetes.

1 reference

12 December 2020

Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets

1 reference

12 December 2020

Autoimmune thyroid disease: further developments in our understanding

1 reference

12 December 2020

Natural killer cell number and function in the spontaneously diabetic BB/W rat

1 reference

12 December 2020

A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis

1 reference

12 December 2020

The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom

1 reference

12 December 2020

Species differences in human and rat islet sensitivity to human cytokines. Monoclonal anti-interleukin-1 (IL-1) influences on direct and indirect IL-1-mediated islet effects

1 reference

12 December 2020

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity

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12 December 2020

IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide

1 reference

12 December 2020

Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.

1 reference

12 December 2020

Immunostimulation circumvents diabetes in NOD/Lt mice

1 reference

12 December 2020

Role of autoantibodies in the pathogenesis and association of endocrine autoimmune disorders

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12 December 2020

Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats

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12 December 2020

Treatment with an interleukin-1 receptor antagonist protein prolongs mouse islet allograft survival

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12 December 2020

Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice.

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12 December 2020

Localization and characterization of interleukin-1 receptors in the islets of Langerhans from control and nonobese diabetic mice

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12 December 2020

Interleukin-1 inhibits glucose-induced Ca2+ uptake by islets of Langerhans

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12 December 2020

T helper cell subsets in insulin-dependent diabetes

1 reference

12 December 2020

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

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12 December 2020

Acceleration of diabetes in young NOD mice with peritoneal macrophages

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12 December 2020

Influence of staurosporine, nitrendipine and monooleoylglycerol on interleukin-1-induced insulin secretion and phosphoinositide hydrolysis

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12 December 2020

On the pathogenesis of insulin-dependent diabetes mellitus

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12 December 2020

IL-1 beta modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat

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12 December 2020

Nicotinamide prevents interleukin-1 effects on accumulated insulin release and nitric oxide production in rat islets of Langerhans

1 reference

12 December 2020

Mechanisms of pancreatic beta-cell destruction in type I diabetes

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12 December 2020

Endogenous nitric oxide induced by interleukin-1 beta in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the 'comet' assay

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12 December 2020

Dissociation between interleukin-1 beta-induced expression of mRNA for superoxide dismutase and nitric oxide synthase in insulin-producing cells

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12 December 2020

Oxygen free radical scavengers protect rat islet cells from damage by cytokines

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12 December 2020

Interleukin-1 promotes hyperglycemia and insulitis in mice normally resistant to streptozotocin-induced diabetes

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12 December 2020

IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.

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12 December 2020

Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor

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12 December 2020

Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury

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12 December 2020

Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection

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12 December 2020

Heat shock protein induction in rat pancreatic islets by recombinant human interleukin 1 beta

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12 December 2020

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

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12 December 2020

Inhibition of Insulin Release after Passive Transfer of Immunoglobulin from Insulin-Dependent Diabetic Children to Mice*

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12 December 2020

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

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12 December 2020

Macrophage-released interleukin-1 in patients with type 1 diabetes mellitus

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12 December 2020

Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase

1 reference

12 December 2020

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

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12 December 2020

Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture

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12 December 2020

Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts

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12 December 2020

Viral infection induces cytokine release by beta islet cells

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12 December 2020

Cell-mediated cytotoxicity

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12 December 2020

Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor

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12 December 2020

Granzyme A is an interleukin 1 beta-converting enzyme

1 reference

12 December 2020

Immune attack on pancreatic islet transplants in the spontaneously diabetic BioBreeding/Worcester (BB/W) rat is not MHC restricted

1 reference

12 December 2020

Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice

1 reference

12 December 2020

Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood.

1 reference

12 December 2020

Influence of protease on inhibitory and stimulatory effects of interleukin 1 beta on beta-cell function

1 reference

12 December 2020

Interleukin-1 induces rapid and transient expression of the c-fos proto-oncogene in isolated pancreatic islets and in purified beta-cells

1 reference

12 December 2020

Prevention of autoimmune diabetes with lymphotoxin in NOD mice

1 reference

12 December 2020

Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells

1 reference

12 December 2020

Tumor necrosis factor production is deficient in diabetes-prone BB rats and can be corrected by complete Freund's adjuvant: a possible immunoregulatory role of tumor necrosis factor in the prevention of diabetes

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12 December 2020

Prediction of insulin dependent diabetes mellitus in non-obese diabetic mice by the endogeneous tumor necrosis factor-alpha level

1 reference

12 December 2020

Role of lymphocyte adhesion receptors in transient interactions and cell locomotion.

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12 December 2020

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

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12 December 2020

Modulation of calcium flux influences interleukin 1 beta effects on insulin release from isolated islets of Langerhans

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12 December 2020

Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus

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12 December 2020

Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are Beta-cell specific

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12 December 2020

Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice

1 reference

12 December 2020

Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1 beta indicate a perturbation in the mitochondrial function

1 reference

12 December 2020

The interleukin-1 family: 10 years of discovery

1 reference

12 December 2020

Cytokines inhibit proliferation and insulin secretion by clonal rat insulinoma cells (RINm5F) non-synergistically and in a pertussis toxin-insensitive manner

1 reference

12 December 2020

Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile

1 reference

12 December 2020

Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction

1 reference

12 December 2020

The effect of HLA and insulin-dependent diabetes mellitus on the secretion levels of tumour necrosis factors alpha and beta and gamma interferon

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12 December 2020

Recombinant interleukin 2 enhances spontaneous insulin-dependent diabetes in BB rats

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12 December 2020

Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats

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12 December 2020

Interleukin-1 stimulates the expression of type I and type II interleukin-1 receptors in the rat insulinoma cell line Rinm5F; sequencing a rat type II interleukin-1 receptor cDNA.

1 reference

12 December 2020

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process

1 reference

12 December 2020

Monocyte Function in IDDM Patients and Healthy Individuals

1 reference

12 December 2020

Interleukin 1 inhibits insulin secretion from isolated rat pancreatic islets by a process that requires gene transcription and mRNA translation

1 reference

12 December 2020

Exogenous administration of IL-1 alpha inhibits active and adoptive transfer autoimmune diabetes in NOD mice

1 reference

12 December 2020

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus

1 reference

12 December 2020

Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis

1 reference

12 December 2020

Immunological aspect of non-obese diabetic mice: immune islet cell-killing mechanism and cell-mediated immunity

1 reference

12 December 2020

Effect of interleukin-2 on diabetes in the BB/Wor rat

1 reference

12 December 2020

Induction of circulating interleukin 10 by interleukin 1 and interleukin 2, but not interleukin 6 immunotherapy

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12 December 2020

Production of and response to interleukin 2 by blood mononuclear cells from some type 1 diabetic patients.

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12 December 2020

Cyclosporin prevents diabetes in BB Wistar rats

1 reference

12 December 2020

A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro

1 reference

12 December 2020

Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-a and TNF-0 by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus

1 reference

12 December 2020

Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus

1 reference

12 December 2020

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus

1 reference

12 December 2020

Studies on autoimmunity for initiation of beta-cell destruction. VI. Macrophages essential for development of beta-cell-specific cytotoxic effectors and insulitis in NOD mice

1 reference

12 December 2020

Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1 beta in the presence of a high glucose concentration.

1 reference

12 December 2020

Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex

1 reference

12 December 2020

Preventive effects of cyclosporin on diabetes in NOD mice

1 reference

12 December 2020

Strain-Dependent Differences in Sensitivity of Rat -Cells to Interleukin 1 In Vitro and In Vivo

1 reference

12 December 2020

Effect of cytokines on "de novo" lipid synthesis and hormone secretion by isolated human islets

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12 December 2020

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1 reference

12 December 2020

Transplacental Passage of Islet Cell Antibody in Infants of Diabetic Mothers

1 reference

12 December 2020

Monokine Antagonism Is Reduced in Patients With IDDM

1 reference

12 December 2020

The enigma of the natural killer cell

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12 December 2020

Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas

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12 December 2020

Liposomal delivery of purified heat shock protein hsp70 into rat pancreatic islets as protection against interleukin 1 beta-induced impaired beta-cell function

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12 December 2020

Effect of macrophage colony-stimulating factor on the development of diabetes mellitus in BB rats

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12 December 2020

CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone

1 reference

12 December 2020

Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

1 reference

12 December 2020

Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins

1 reference

12 December 2020

Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric-oxide.

1 reference

12 December 2020

Interleukin-1beta-mediated beta-cell inhibition in vivo.

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12 December 2020

Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.

1 reference

12 December 2020

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1 reference

12 December 2020

Induction of type I diabetes by interferon-alpha in transgenic mice

1 reference

12 December 2020

Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells

1 reference

12 December 2020

Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. The Canadian-European Randomized Control Trial Group

1 reference

12 December 2020

Low serum levels of tumor necrosis factor-alpha in insulin-dependent diabetic children

1 reference

12 December 2020

In vitro secretion of interleukin-1 beta and interferon-gamma by peripheral blood lymphomononuclear cells in diabetic patients

1 reference

12 December 2020

Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets

1 reference

12 December 2020

Islet cell DNA is a target of inflammatory attack by nitric oxide

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12 December 2020

Interleukin 1 inhibits insulin secretion from isolated perifused rat islets

1 reference

12 December 2020

Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis

1 reference

12 December 2020

Inhibition of type 1 diabetes in BB rats with recombinant human tumor necrosis factor-alpha

1 reference

12 December 2020

Progression to diabetes in nonobese diabetic (NOD) mice with transgenic T cell receptors

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12 December 2020

Interleukin-1 induction of tumor necrosis factor-alpha mRNA and bioactive tumor necrosis factor-alpha in a pancreatic beta-cell line by a mechanism requiring no de novo protein synthesis

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12 December 2020

In vivo administration of interleukin-1 inhibits glucose-stimulated insulin release

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12 December 2020

Immune islet killing mechanisms associated with insulin-dependent diabetes: in vitro expression of cellular and antibody-mediated islet cell cytotoxicity in humans

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12 December 2020

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice

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12 December 2020

Administration of silica prevents diabetes in BB-rats

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12 December 2020

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients

1 reference

12 December 2020

Granzymes: exogenous proteinases that induce target cell apoptosis.

1 reference

12 December 2020

Lack of predictive value of islet cell antibodies, insulin antibodies, and HLA-DR phenotype for remission in cyclosporin-treated IDDM patients. The Canadian-European Randomized Control Trial Group

1 reference

12 December 2020

Interaction of interleukin-1 with islet beta-cells. Distinction between indirect, aspecific cytotoxicity and direct, specific functional suppression

1 reference

12 December 2020

A role for tyrosine kinase activation in interleukin-1 beta induced nitric oxide production in the insulin producing cell line RINm-5F.

1 reference

12 December 2020

Studies on autoimmunity for initiation of beta-cell destruction. V. Decrease of macrophage-dependent T lymphocytes and natural killer cytotoxicity in silica-treated BB rats.

1 reference

12 December 2020

Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma

1 reference

12 December 2020

Cytokines and the endocrine system. II. Roles in substrate metabolism, modulation of thyroidal and pancreatic endocrine cell functions and autoimmune endocrine diseases.

1 reference

12 December 2020

Poly I:C induces development of diabetes mellitus in BB rat

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12 December 2020

Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse

1 reference

12 December 2020

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1 reference

12 December 2020

Human T lymphocyte subsets. Functional heterogeneity and surface recognition structures

1 reference

12 December 2020

Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice

1 reference

12 December 2020

Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets

1 reference

12 December 2020

Interleukin-1β induces the expression of HSP70, heme oxygenase and Mn-SOD in FACS-purified rat islet β-cells, but not in α-cells

1 reference

12 December 2020

Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines. Viability, secretory function, and MHC antigen expression

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12 December 2020

Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice

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12 December 2020

Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas

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12 December 2020

Reduction in insulitis following administration of IFN-gamma and TNF-alpha in the NOD mouse

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12 December 2020

Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas

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12 December 2020

Cytotoxic effect of IFN-gamma plus TNF-alpha on human islet cells

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12 December 2020

Interleukin-1 signal transduction.

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12 December 2020

Prevention of type I diabetes with lymphotoxin in BB rats

1 reference

12 December 2020

Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

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12 December 2020

Islet expression of interferon-alpha precedes diabetes in both the BB rat and streptozotocin-treated mice

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12 December 2020

Evidence for IL-6 production by and effects on the pancreatic beta-cell

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12 December 2020

Interleukin 1-induced prostaglandin E2 accumulation by isolated pancreatic islets

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12 December 2020

Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion.

1 reference

12 December 2020

In vitro production of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in insulin-dependent diabetes mellitus

1 reference

12 December 2020

Lymphokine production in allografts--analysis of RNA by northern blotting

1 reference

12 December 2020

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases

1 reference

12 December 2020

A role for macrophages in the pathogenesis of type 1 diabetes

1 reference

12 December 2020

Apoptosis and programmed cell death in immunity

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12 December 2020

Low-dose streptozocin-induced diabetes in mice. Electron microscopy reveals single-cell insulitis before diabetes onset.

1 reference

12 December 2020

Interleukin-1β Induces an Early Decrease in Insulin Release, (Pro)Insulin Biosynthesis and Insulin Mrna in Mouse Pancreatic Islets by a Mechanism Dependent on Gene Transcription and Protein Synthesis

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12 December 2020

Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic beta-cells: induction of argininosuccinate synthetase by cytokines

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12 December 2020

Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1 beta (IL-1 beta) without affecting glutamate decarboxylase expression or nitric oxide production

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12 December 2020

Ceramide inhibits pancreatic beta-cell insulin production and mitogenesis and mimics the actions of interleukin-1 beta

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12 December 2020

Inhibition of nitric oxide generation affects the induction of diabetes by streptozocin in mice

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12 December 2020

Simulation of the diffusion and reaction of endogenously produced nitric oxide

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12 December 2020

Interleukin 4 impairs rat pancreatic islet function in vitro by an action different to that of interleukin 1

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12 December 2020

Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development

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12 December 2020

Insulin-secreting beta-cells possess specific receptors for interleukin-1 beta

1 reference

12 December 2020

IL-1 induces intracisternal type A virus and retrovirus type C in pancreatic beta-cells of NOD mice.

1 reference

12 December 2020

Occurrence of IDDM during interferon therapy for chronic viral hepatitis

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12 December 2020

Spontaneous cytotoxicity of macrophages against pancreatic islet cells.

1 reference

12 December 2020

Adrenalectomy enhances the susceptibility of pancreatic islets to interleukin-1 beta: immunohistochemical study

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12 December 2020

Pathogenesis of multiple sclerosis

1 reference

12 December 2020

Perforin: structure and function

1 reference

12 December 2020

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans

1 reference

12 December 2020

Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation

1 reference

12 December 2020

Mechanisms of self tolerance

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12 December 2020

Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta

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12 December 2020

Macrophage-mediated cytotoxicity against cultured pancreatic islet cells.

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12 December 2020

Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus

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12 December 2020

Interleukins increase surface ganglioside expression of pancreatic islet cellsin vitro

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12 December 2020

Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity

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12 December 2020

Antibodies to glutamic acid decarboxylase induced by interferon-alpha therapy for chronic viral hepatitis

1 reference

12 December 2020

Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis

1 reference

12 December 2020

In situ islet cytokine gene expression during development of type I diabetes in the non-obese diabetic mouse

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12 December 2020

Prevention of diabetes in BB/Wor rats treated with monoclonal antibodies to interferon-gamma

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12 December 2020

Interleukin-1 inhibits glucose-modulated insulin and glucagon secretion in rat islet monolayer cultures

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12 December 2020

The functional role of CD8+ T helper type 2 cells

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12 December 2020

Repetitive exposure of pancreatic islets to interleukin-1 beta. An in vitro model of pre-diabetes?

1 reference

12 December 2020

An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1?

1 reference

12 December 2020

High stimulatory activity of dendritic cells from diabetes-prone BioBreeding/Worcester rats exposed to macrophage-derived factors

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12 December 2020

The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration

1 reference

12 December 2020

The biological properties of interleukin-1.

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12 December 2020

Two-dimensional gel electrophoresis of rat islet proteins. Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide

1 reference

12 December 2020

Effect of probucol on development of diabetes mellitus in BB rats

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12 December 2020

Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes.

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12 December 2020

Functional characteristics of rat pancreatic islets maintained in culture after exposure to human interleukin 1

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12 December 2020

CD8+ T-cells are required for adoptive transfer of the BB rat diabetic syndrome

1 reference

12 December 2020

Environmental risk factors in human type 1 diabetes--an epidemiological perspective.

1 reference

12 December 2020

Islet cell autoantibodies: pathobiology and clinical applications

1 reference

12 December 2020

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice

1 reference

12 December 2020

Interleukin 1 is potent modulator of insulin secretion from isolated rat islets of Langerhans

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12 December 2020

Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production

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12 December 2020

Effects of cytokines on rat pancreatic islet cell monolayer cultures: distinction between functional and cytotoxic effects on islet beta-cells

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12 December 2020

Interleukin 1 is a potent stimulator of islet insulin secretion and phosphoinositide hydrolysis

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12 December 2020

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

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12 December 2020

Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans

1 reference

12 December 2020

N omega-nitro-L-arginine methyl ester reduces the incidence of IDDM in BB/E rats

1 reference

12 December 2020

Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group

1 reference

12 December 2020

Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans.

1 reference

12 December 2020

Interrelationship of changes in islet nicotine adeninedinucleotide, insulin secretion, and cell viability induced by interleukin-1 beta

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12 December 2020

Spontaneous diabetes mellitus in the Bio-Breeding/Worcester rat. Evidence in vitro for natural killer cell lysis of islet cells

1 reference

12 December 2020

Lymphoid cells of BB/W diabetic rats are cytotoxic to islet beta cells in vitro.

1 reference

12 December 2020

Effects of prolonged exposure in vitro to interferon-gamma and tumour necrosis factor-alpha on nitric oxide and insulin production of rat pancreatic islets

1 reference

12 December 2020

Differential interleukin-1 receptor antagonism on pancreatic beta and alpha cells. Studies in rodent and human islets and in normal rats

1 reference

12 December 2020

Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4

1 reference

12 December 2020

Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients

1 reference

12 December 2020

Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide

1 reference

12 December 2020

Association of polymorphism in the interferon gamma gene with IDDM

1 reference

12 December 2020

Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats

1 reference

12 December 2020

Serum biopterin--a novel marker for immune activation during pre-diabetes in the BB rat.

1 reference

12 December 2020

A genome-wide search for human type 1 diabetes susceptibility genes

1 reference

12 December 2020

Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice

1 reference

12 December 2020

Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.

1 reference

12 December 2020

Studies on Autoimmunity for T-Cell-Mediated β-Cell Destruction: Distinct Difference in β-Cell Destruction Between CD4+ and CD8+ T-Cell Clones Derived From Lymphocytes Infiltrating the Islets of NOD Mice

1 reference

12 December 2020

Sensitivity of insulin-secreting RIN m5F cells to undergoing apoptosis by the protein kinase C inhibitor staurosporine

1 reference

12 December 2020

Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans

1 reference

12 December 2020

Adoptive T cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes

1 reference

12 December 2020

Cytokine gene expression in the islets of the diabetic Biobreeding/Worcester rat

1 reference

12 December 2020

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion

1 reference

12 December 2020

Predominance of stimulatory effects of interleukin-1 beta on isolated human pancreatic islets

1 reference

12 December 2020

Imbalance of the interleukin 2 system in children with IDDM

1 reference

12 December 2020

The effect of nitric oxide donors on insulin secretion, cyclic GMP and cyclic AMP in rat islets of Langerhans and the insulin-secreting cell lines HIT-T15 and RINm5F.

1 reference

12 December 2020

T-cell interactions in autoimmunity: insights from a murine model of graft-versus-host disease

1 reference

12 December 2020

Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism

1 reference

12 December 2020

Macrophage-mediated islet cell cytotoxicity in BB rats.

1 reference

12 December 2020

Short exposure of rat pancreatic islets to interleukin-1 beta induces a sustained but reversible impairment in beta-cell function: influence of protease activation, gene transcription, and protein synthesis

1 reference

12 December 2020

Effect of cyclosporin A treatment on the production of antibody in insulin-dependent (type I) diabetic patients

1 reference

12 December 2020

Interleukin-1 beta regulates the expression of a leukocyte type of 12-lipoxygenase in rat islets and RIN m5F cells.

1 reference

12 December 2020

Characterization of polymorphisms of an interleukin 1 receptor type 1 gene (IL1RI) promotor region (P2) and their relation to insulin-dependent diabetes mellitus (IDDM). The Danish Study Group of Diabetes in Childhood.

1 reference

12 December 2020

Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice

1 reference

12 December 2020

Human interleukin 1 beta stimulates islet insulin release by a mechanism not dependent on changes in phospholipase C and protein kinase C activities or Ca2+ handling.

1 reference

12 December 2020

Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice

1 reference

12 December 2020

Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines (HIT-T15 and NIT-1) confers resistance against interleukin-1-induced nitric oxide production

1 reference

12 December 2020

Cytokine production in patients with newly diagnosed insulin-dependent (type I) diabetes mellitus

1 reference

12 December 2020

Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial.

1 reference

12 December 2020

A 1-hour pulse with IL-1 beta induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism.

1 reference

12 December 2020

Interleukin-1 beta induced activation of NF-kappa B in insulin producing RINm5F cells is prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone

1 reference

12 December 2020

Nitric oxide and nitric oxide synthase mRNA induction in mouse islet cells by interferon-gamma plus tumor necrosis factor-alpha

1 reference

12 December 2020

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans

1 reference

12 December 2020

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1 reference

12 December 2020

Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor

1 reference

12 December 2020

The specificity of rejection and the absence of susceptibility of pancreatic islet beta cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat.

1 reference

12 December 2020

Multiple immunological abnormalities in patients with type 1 (insulin-dependent) diabetes mellitus

1 reference

12 December 2020

Mechanisms of cytokine-induced destruction of rat insulinoma cells: the role of nitric oxide.

1 reference

12 December 2020

TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide

1 reference

12 December 2020

Genetic requirements for acceleration of diabetes in non-obese diabetic mice expressing interleukin-2 in islet beta-cells

1 reference

12 December 2020

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies

1 reference

12 December 2020

Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat

1 reference

12 December 2020

Effect of GK1.5 monoclonal antibody dosage on survival of pig proislet xenografts in CD4+ T cell-depleted mice.

1 reference

12 December 2020

Insulitis in type 1 (insulin-dependent) diabetes mellitus in man--macrophages, lymphocytes, and interferon-gamma containing cells

1 reference

12 December 2020

Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats

1 reference

12 December 2020

Comparison of mRNA contents of interleukin-1 beta and nitric oxide synthase in pancreatic islets isolated from female and male nonobese diabetic mice

1 reference

12 December 2020

Pyrrolidine dithiocarbamate prevents IL-1-induced nitric oxide synthase mRNA, but not superoxide dismutase mRNA, in insulin producing cells.

1 reference

12 December 2020

Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

1 reference

12 December 2020

Characterization of mixed syngeneic-allogeneic and syngeneic-xenogeneic islet-graft rejections in mice. Evidence of functional impairment of the remaining syngeneic islets in xenograft rejections

1 reference

12 December 2020

Identifiers

DOI

10.1007/S001250050548

1 reference

27 September 2017

1 reference

PubMed ID

8877284