p21ras in carcinogenesis (Q41176238)

27 September 2017

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title

p21ras in carcinogenesis (English)

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27 September 2017

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de Vries JE

1

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27 September 2017

ten Kate J

series ordinal

2

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27 September 2017

Bosman FT

series ordinal

3

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27 September 2017

publication date

1 July 1996

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Pathology, Research and Practice

27 September 2017

published in

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27 September 2017

volume

192

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27 September 2017

issue

7

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27 September 2017

page(s)

658-668

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Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability

27 September 2017

cites work

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7 January 2021

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

1 reference

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7 January 2021

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7 January 2021

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

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7 January 2021

Proteins regulating Ras and its relatives

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7 January 2021

The GTPase superfamily: conserved structure and molecular mechanism

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Oncogenes and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Inhibition by cAMP of Ras-Dependent Activation of Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The GRB2/Sem-5 adaptor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The role of c-myc in cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Activation of Raf-1 by 14-3-3 proteins

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Bcl-2 associates with the ras-related protein R-ras p23

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes.

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The glucose transporter family: structure, function and tissue-specific expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Mechanism of inhibition of Raf-1 by protein kinase A.

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Mutational activation of c-raf-1 and definition of the minimal transforming sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Mediation of c-Myc-induced apoptosis by p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Apoptosis induced by anticancer drugs

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Function of a human cyclin gene as an oncogene

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

H-ras expression, genetic instability, and acquisition of metastatic ability by rat prostatic cancer cells following v-H-ras oncogene transfection

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Immortalization by c-myc, H-ras, and Ela oncogenes induces differential cellular gene expression and growth factor responses

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The ras signaling pathway mimics insulin action on glucose transporter translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

How cells cycle toward cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Growth factors, mitogens, oncogenes and the regulation of glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Principles of CDK regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Protein modules and signalling networks

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Rac mediates growth factor-induced arachidonic acid release.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

1 reference

7 January 2021

Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Growth factors: regulation of normal and neoplastic growth

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Bcl-2 and the regulation of programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Identification of a ten-amino acid proline-rich SH3 binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Differential requirement for p21ras activation in the metabolic signaling by insulin.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

G1 phase progression: cycling on cue

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Signal transduction by receptors with tyrosine kinase activity

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Cloning of bovine GAP and its interaction with oncogenic ras p21.

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

p53 function and dysfunction

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Transfected c-Ha-ras oncogene enhances karyotypic instability and integrates predominantly in aberrant chromosomes

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

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https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

The neurofibromatosis type 1 gene encodes a protein related to GAP

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0344-0338%2896%2980087-2

7 January 2021

10.1016/S0344-0338(96)80087-2

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