The biostructural pathology of the serpins: critical function of sheet opening mechanism (Q41224616)

28 September 2017

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title

The biostructural pathology of the serpins: critical function of sheet opening mechanism (English)

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28 September 2017

Carrell RW

1

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28 September 2017

Stein PE

series ordinal

2

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28 September 2017

publication date

1 January 1996

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Biological chemistry Hoppe-Seyler

28 September 2017

published in

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28 September 2017

volume

377

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28 September 2017

issue

1

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28 September 2017

page(s)

1-17

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Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

28 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Proposed heparin binding site in antithrombin based on arginine 47. A new variant Rouen-II, 47 Arg to Ser

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Carboxy terminal fragment of human α-1-antitrypsin from hydroxylamine clevage: Homology with antithrombin III

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Biological implications of a 3 A structure of dimeric antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Linkage of the Angiotensinogen Gene to Essential Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Serpins: implications of a mobile reactive centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Modeling the intact form of the alpha 1-proteinase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Divining the serpin inhibition mechanism: a suicide substrate 'springe'?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

S-ovalbumin, an ovalbumin conformer with properties analogous to those of loop-inserted serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Characterization of α1-Antitrypsin in the Inclusion Bodies from the Liver in α1-Antitrypsin Deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Molecular basis of human hypertension: role of angiotensinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Antithrombin III Toyama: replacement of arginine-47 by cysteine in hereditary abnormal antithrombin III that lacks heparin-binding ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Protein inhibitors of proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Antithrombin-TRI (Ala382 to Thr) causing severe thromboembolic tendency undergoes the S-to-R transition and is associated with a plasma-inactive high-molecular-weight complex of aggregated antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Evolutionary relationships among the serpins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Structural basis of latency in plasminogen activator inhibitor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Secondary structure changes stabilize the reactive-centre cleaved form of SERPINs. A study by 1H nuclear magnetic resonance and Fourier transform infrared spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

What do dysfunctional serpins tell us about molecular mobility and disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Serpin tertiary structure transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Ovalbumin and angiotensinogen lack serpin S-R conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Human plasma proteinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

The inhibition mechanism of serpins. Evidence that the mobile reactive center loop is cleaved in the native protease-inhibitor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin. Its relationship to the structure of cleaved alpha-1-proteinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Crystallization and Preliminary X-ray Diffraction Analysis of Two Conformations of Intact Human Antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

Mobile reactive centre of serpins and the control of thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBCHM3.1996.377.1.1

10.1515/BCHM3.1996.377.1.1

21 January 2018

Identifiers

DOI

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28 September 2017

1 reference