Chemoprotection of normal tissues by transfer of drug resistance genes (Q41349090)

29 September 2017

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title

Chemoprotection of normal tissues by transfer of drug resistance genes (English)

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29 September 2017

J A Rafferty

1

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29 September 2017

I Hickson

2

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29 September 2017

N Chinnasamy

3

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29 September 2017

L S Lashford

4

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29 September 2017

G P Margison

5

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29 September 2017

T M Dexter

6

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29 September 2017

L J Fairbairn

7

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29 September 2017

1 September 1996

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Cancer and Metastasis Reviews

29 September 2017

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29 September 2017

15

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29 September 2017

3

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29 September 2017

365-383

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https://scigraph.springernature.com/pub.10.1007/bf00046348

29 September 2017

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12 December 2020

Circumvention of resistance to anthracyclines by calcium antagonists and other membrane-perturbing agents

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12 December 2020

O6 alkylguanine-DNA alkyltransferase activity in human myeloid cells

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12 December 2020

Transduction of MDR1 into human and mouse haemopoietic progenitor cells: use of rhodamine (Rh123) to determine transduction frequency and in vivo selection.

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12 December 2020

Ligand-directed retroviral targeting of human breast cancer cells

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12 December 2020

Mobilization of CD34-positive tumour cells in a patient with testicular mixed germ cell tumour

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12 December 2020

Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.

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12 December 2020

Genes amplified and overexpressed in human multidrug-resistant cell lines

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12 December 2020

Secondary malignancies following cancer chemotherapy.

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12 December 2020

Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

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12 December 2020

CD34 immunoexpression in stromal tumours of the gastrointestinal tract and in mesenteric fibromatoses

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12 December 2020

Molecular cloning and chromosomal localization of the human thrombopoietin gene.

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12 December 2020

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12 December 2020

Preselection of transduced murine hematopoietic stem cell populations leads to increased long-term stability and expression of the human multiple drug resistance gene

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12 December 2020

DNA cross-linking by chloroethylating agents

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12 December 2020

Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex.

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12 December 2020

Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.

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12 December 2020

Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene

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12 December 2020

Genetic toxicity and potential carcinogenicity of taxol

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12 December 2020

Transfer and expression of the human multiple drug resistance gene in human CD34+ cells

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12 December 2020

Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells.

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12 December 2020

High-dose therapy with autologous bone marrow transplantation for the treatment of solid tumors

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12 December 2020

Genetic analysis of the multidrug transporter

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12 December 2020

Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung

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12 December 2020

Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells.

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12 December 2020

Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation

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12 December 2020

Growth and differentiation in the hemopoietic system

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12 December 2020

The use of DNA viruses as vectors for gene therapy

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12 December 2020

Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance

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12 December 2020

Recombinant human erythropoietin treatment in elderly cancer patients with cisplatin-associated anemia

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12 December 2020

Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.

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12 December 2020

Colony-stimulating factors in the clinic

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12 December 2020

A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.

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12 December 2020

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents

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12 December 2020

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization

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12 December 2020

Inhibitor of stem cell proliferation in normal bone marrow

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12 December 2020

Harvey murine sarcoma virus/MDR1 retroviral vectors: efficient virus production and foreign gene transduction using MDR1 as a selectable marker

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12 December 2020

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation.

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12 December 2020

A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance reg

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12 December 2020

Phase II studies of mitozolomide in melanoma, lung and ovarian cancer

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12 December 2020

Human APC gene expression in rodent colonic epithelium in vivo using liposomal gene delivery

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12 December 2020

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

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12 December 2020

Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cells

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12 December 2020

The iatrogenic leukaemias induced by radio- and/or chemotherapy

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12 December 2020

Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice

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12 December 2020

O6-methylguanine-induced replication blocks.

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12 December 2020

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.

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12 December 2020

Use of retroviral vectors for gene transfer and expression

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12 December 2020

Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer

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12 December 2020

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

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12 December 2020

Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells.

1 reference

12 December 2020

1 reference

12 December 2020

Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery

1 reference

12 December 2020

High-dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas

1 reference

12 December 2020

Rapid haematological recovery after high-dose consolidation chemotherapy with peripheral blood progenitor cells (PBPC) as sole source of support collected at a single apheresis

1 reference

12 December 2020

Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor

1 reference

12 December 2020

Retroviral Coexpression of a Multidrug Resistance Gene (MDR1) and Humanα-Galactosidase A for Gene Therapy of Fabry Disease

1 reference

12 December 2020

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine

1 reference

12 December 2020

The human CD34 hematopoietic stem cell antigen promoter and a 3' enhancer direct hematopoietic expression in tissue culture

1 reference

12 December 2020

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes

1 reference

12 December 2020

On the quantitative relationship between O6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer- human tumor cell line

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12 December 2020

Tissue-specific targeting of retroviral vectors through ligand-receptor interactions

1 reference

12 December 2020

Bicistronic and two-gene retroviral vectors for using MDR1 as a selectable marker and a therapeutic gene

1 reference

12 December 2020

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1 reference

12 December 2020

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

1 reference

12 December 2020

Multiple drug resistance, the MDR gene, and the law of maximum perversity as it applies to oncology: an hypothesis

1 reference

12 December 2020

Transfer of the CFTR Gene to the Lung of Nonhuman Primates with E1-Deleted, E2a-Defective Recombinant Adenoviruses: A Preclinical Toxicology Study

1 reference

12 December 2020

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation

1 reference

12 December 2020

The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice.

1 reference

12 December 2020

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

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12 December 2020

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

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12 December 2020

Chemotherapy resistance to taxol in clonogenic progenitor cells following transduction of CD34 selected marrow and peripheral blood cells with a retrovirus that contains the MDR-1 chemotherapy resistance gene.

1 reference

12 December 2020

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

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12 December 2020

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

1 reference

12 December 2020

Macrophage-inflammatory protein protects multipotent hematopoietic cells from the cytotoxic effects of hydroxyurea in vivo

1 reference

12 December 2020

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia

1 reference

12 December 2020

Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity

1 reference

12 December 2020

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

1 reference

12 December 2020

Multicyclic, dose-intensive chemotherapy supported by sequential reinfusion of hematopoietic progenitors in whole blood

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12 December 2020

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

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12 December 2020

Transduction of NIH 3T3 cells with a retrovirus carrying both human MDR1 and glutathione S-transferase pi produces broad-range multidrug resistance

1 reference

12 December 2020

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent

1 reference

12 December 2020

Expression in mammalian cells of a truncated Escherichia coli gene coding for O6-alkylguanine alkyltransferase reduces the toxic effects of alkylating agents.

1 reference

12 December 2020

Human MDR gene transfer in patients with advanced cancer.

1 reference

12 December 2020

An approach for the analysis of relapse and marrow reconstitution after autologous marrow transplantation using retrovirus-mediated gene transfer

1 reference

12 December 2020

In vivo models of P-glycoprotein-mediated multidrug resistance

1 reference

12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

12 December 2020

Long-term protection of hematopoiesis against the cytotoxic effects of multiple doses of nitrosourea by retrovirus-mediated expression of human O6-alkylguanine-DNA-alkyltransferase

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12 December 2020

Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model

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12 December 2020

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation.

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12 December 2020

Stem cell factor, interleukin-3, and interleukin-6 promote retroviral-mediated gene transfer into murine hematopoietic stem cells

1 reference

12 December 2020

O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.

1 reference

12 December 2020

Recombinant human erythropoietin therapy for anemic cancer patients on combination chemotherapy

1 reference

12 December 2020

Total marrow failure induced by pegylated stem-cell factor administered before 5-fluorouracil.

1 reference

12 December 2020

Growth Factor-Assisted Chemotherapy-The Manchester Experience

1 reference

12 December 2020

Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase.

1 reference

12 December 2020

1 reference

12 December 2020

Functional characterization of the promoter for the gene encoding human eosinophil peroxidase

1 reference

12 December 2020

Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes

1 reference

12 December 2020

Dose-escalating induction chemotherapy supported by lenograstim preceding high-dose consolidation chemotherapy for advanced breast cancer. Selection of the most acceptable regimen to induce maximal tumor response and investigation of the optimal tim

1 reference

12 December 2020

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

1 reference

12 December 2020

Clinical and in vitro effects of recombinant human erythropoietin in patients receiving intensive chemotherapy for small-cell lung cancer

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12 December 2020

Mechanisms of carcinogenesis induced by alkylating agents

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12 December 2020

Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo

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12 December 2020

Tissue-specific targeting of cytokine unresponsiveness in transgenic mice

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12 December 2020

Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents.

1 reference

12 December 2020

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo

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12 December 2020

Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells.

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12 December 2020

Functional isolation and characterization of human hematopoietic stem cells

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12 December 2020

Identifiers

DOI

10.1007/BF00046348

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Dimensions Publication ID

29 September 2017

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