Structure, function and regulation of Ca2+-sensitive cytosolic phospholipase A2 (cPLA2). (Q41554049)

3 October 2017

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title

Structure, function and regulation of Ca2+-sensitive cytosolic phospholipase A2 (cPLA2). (English)

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3 October 2017

R M Kramer

1

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PubMed ID

9247121

3 October 2017

J D Sharp

series ordinal

2

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PubMed ID

9247121

3 October 2017

language of work or name

English

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publication date

1 June 1997

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3 October 2017

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3 October 2017

410

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3 October 2017

1

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3 October 2017

49-53

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Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

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Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells

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Arachidonic acid metabolism

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Cytosolic phospholipase A2

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Mammalian calcium-independent phospholipase A2.

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Isolation of promoter for cytosolic phospholipase A2 (cPLA2).

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Identification of a 27 bp 5'-flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene

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5'-flanking region surrounding a human cytosolic phospholipase A2 gene

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Transmembrane signaling in kidney health and disease

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Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers

21 January 2018

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Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

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Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2.

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Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine

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How MAP kinases are regulated

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Metal ion and salt effects on the phospholipase A2, lysophospholipase, and transacylase activities of human cytosolic phospholipase A2.

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Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: application to the determination of substrate preferences

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cPLA2 is phosphorylated and activated by MAP kinase

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Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets

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p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2

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Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation.

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Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat.

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Cytolytic and membrane-perturbing properties of lysophosphatidylcholine

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Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes

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Complete discrimination of docosahexaenoate from arachidonate by 85 kDa cytosolic phospholipase A2 during the hydrolysis of diacyl- and alkenylacylglycerophosphoethanolamine

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Cytosolic Phospholipase A2 Is Phosphorylated in Collagen- and Thrombin-stimulated Human Platelets Independent of Protein Kinase C and Mitogen-activated Protein Kinase

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Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. Evidence for activation of cPLA2 independent of the mitogen-activated protein kinases ERK1/2

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Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum

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Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases.

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7 January 2021

Identifiers

DOI

1 reference

3 October 2017

1 reference

PubMed ID

9247121