clavulanic acid Béarla (Q415709)

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Β-lactam molecule used as β-lactamase inhibitor to overcome antibiotic resistance in bacteria Béarla
cuir in eagar
Language Label Description Also known as
Gaeilge
No label defined
No description defined
    Béarla
    clavulanic acid
    Β-lactam molecule used as β-lactamase inhibitor to overcome antibiotic resistance in bacteria
    • (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
    • (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
    • Clavulanic Acid
    • Clavulansaeure
    • Acidum clavulanicum
    • Acide clavulanique
    • MM 14151
    • Acido clavulanico
    • Antibiotic mm 14151
    • BRL-14151
    • ácido clavulánico
    • Clavulansäure
    • clavulonic acid
    • Clavulanate
    • acide clavulanique
    • Antibiotic MM 14151
    • Clavulanic acid

    Statements

    fo-aicme de
    alcalóideach
    0 references
    úsáid
    cógas
    1 reference
    teideal
    Clavulanate (Béarla)
    ráite i
    DrugBank Béarla
    teanga an tsaothair nó an ainm
    Béarla
    dáta foilsithe
    17 Samhain 2015
    DrugBank ID Béarla
    00766
    struchtúr ceimiceach
    Clavulanic acid.svg
    512 × 360; 5 KB
    0 references
    mais
    199.048 aonad maise adamhaí
    1 reference
    ráite i
    PubChem Béarla
    PubChem CID Béarla
    5280980
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    CLAVULANIC ACID (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    foirmle cheimiceach
    C₈H₉NO₅
    1 reference
    ráite i
    PubChem Béarla
    PubChem CID Béarla
    5280980
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    CLAVULANIC ACID (Béarla)
    dáta rochtana
    19 Samhain 2016
    SMILES canónta
    C1C2N(C1=O)C(C(=CCO)O2)C(=O)O
    1 reference
    ráite i
    PubChem Béarla
    PubChem CID Béarla
    5280980
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    CLAVULANIC ACID (Béarla)
    dáta rochtana
    19 Samhain 2016
    SMILES isiméireach
    C1[C@@H]2N(C1=O)[C@H](/C(=C/CO)/O2)C(=O)O
    1 reference
    ráite i
    PubChem Béarla
    PubChem CID Béarla
    5280980
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    CLAVULANIC ACID (Béarla)
    dáta rochtana
    19 Samhain 2016
    tacsón ina n-aimsítear é
    Streptomyces clavuligerus
    69 references
    ráite i
    The origin of the β-lactam carbons of clavulanic acid Béarla
    ráite i
    Evidence that arginine is a later metabolic intermediate than ornithine in the biosynthesis of clavulanic acid by Streptomyces clavuligerus Béarla
    ráite i
    Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue Béarla
    ráite i
    Biosynthesis of clavulanic acid: origin of the C3 unit Béarla
    ráite i
    Biosynthesis of clavulanic acid: origin of the C5 unit Béarla
    ráite i
    The stereochemical fate of (2RS,5R)- and (2RS,5S)-[5-3H]ornithine in clavulanic acid biosynthesis Béarla
    ráite i
    Clavulanic acid biosynthesis: the stereochemical course of β-lactam formation from chiral glycerol Béarla
    ráite i
    The role of molecular oxygen in clavulanic acid biosynthesis: evidence for a bacterial oxidative deamination Béarla
    ráite i
    Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis Béarla
    ráite i
    A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source. Béarla
    ráite i
    Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1. Béarla
    ráite i
    Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model Béarla
    ráite i
    Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus Béarla
    ráite i
    A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications Béarla
    ráite i
    An improved HPLC-DAD method for clavulanic acid quantification in fermentation broths of Streptomyces clavuligerus. Béarla
    ráite i
    Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus Béarla
    ráite i
    Homologous expression of lysA encoding diaminopimelic acid (DAP) decarboxylase reveals increased antibiotic production in Streptomyces clavuligerus Béarla
    ráite i
    The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene Béarla
    ráite i
    Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways Béarla
    ráite i
    A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus Béarla
    ráite i
    Clavulanic acid production estimation based on color and structural features of Streptomyces clavuligerus bacteria using self-organizing map and genetic algorithm. Béarla
    ráite i
    Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus Béarla
    ráite i
    Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus Béarla
    ráite i
    Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus Béarla
    ráite i
    Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus Béarla
    ráite i
    Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus Béarla
    ráite i
    Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes Béarla
    ráite i
    A statistical approach using L(25) orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142. Béarla
    ráite i
    Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus Béarla
    ráite i
    5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus. Béarla
    ráite i
    Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064. Béarla
    ráite i
    In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus Béarla
    ráite i
    Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture Béarla
    ráite i
    5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus Béarla
    ráite i
    Improved production of clavulanic acid by reverse engineering and overexpression of the regulatory genes in an industrial Streptomyces clavuligerus strain Béarla
    ráite i
    Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus Béarla
    ráite i
    Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene Béarla
    ráite i
    Role of σ-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585. Béarla
    ráite i
    Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus Béarla
    ráite i
    Enhanced biosynthesis of clavulanic acid in Streptomyces clavuligerus due to oxidative challenge by redox-cycling agents Béarla
    ráite i
    High concentrations of clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus Béarla
    ráite i
    Characterization of the Metabolic Response of Streptomyces clavuligerus to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production Béarla
    ráite i
    Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant Béarla
    ráite i
    A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus Béarla
    ráite i
    Streptomyces clavuligerus shows a strong association between TCA cycle intermediate accumulation and clavulanic acid biosynthesis. Béarla
    ráite i
    Activation of Secondary Metabolite Gene Clusters in by the PimM Regulator of Béarla
    ráite i
    Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites. Béarla
    ráite i
    Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Béarla
    ráite i
    Dissociation of cephamycin C and clavulanic acid biosynthesis by 1,3-diaminopropane in Streptomyces clavuligerus. Béarla
    ráite i
    Production of clavulanic acid and cephamycin C by Streptomyces clavuligerus in palm-oil medium Béarla
    ráite i
    An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus Béarla
    ráite i
    Improvement for the production of clavulanic acid by mutant Streptomyces clavuligerus Béarla
    ráite i
    Screening of medium constituents for clavulanic acid production by Streptomyces clavuligerus. Béarla
    ráite i
    A quantitative approach to characterizing cell lysis caused by mechanical agitation of Streptomyces clavuligerus. Béarla
    ráite i
    Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus Béarla
    ráite i
    Morphology and clavulanic acid production of Streptomyces clavuligerus: Effect of stirrer speed in batch fermentations Béarla
    ráite i
    Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis Béarla
    ráite i
    Complete Genome Sequence of Streptomyces clavuligerus F613-1, an Industrial Producer of Clavulanic Acid Béarla
    ráite i
    The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in F613-1 Béarla
    ráite i
    An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus Béarla
    ráite i
    Shear conditions in clavulanic acid production by Streptomyces clavuligerus in stirred tank and airlift bioreactors. Béarla
    ráite i
    Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement Béarla
    ráite i
    The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant Béarla
    ráite i
    Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus Béarla
    ráite i
    Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp Béarla
    ráite i
    Application of Acid and Cold Stresses to Enhance the Production of Clavulanic Acid by Streptomyces clavuligerus Béarla
    ráite i
    Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus Béarla
    ráite i
    Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus. Béarla
    ráite i
    Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus Béarla
    codanna
    carbón
    0 references
    catagóir Commons
    Clavulanic acid
    0 references

    Identifiers

    ChemSpider ID Béarla
    4444466
    1 reference
    ráite i
    ChemSpider Béarla
    ChemSpider ID Béarla
    4444466
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    clavulanic acid (Béarla)
    dáta rochtana
    19 Samhain 2016
    PubChem CID Béarla
    5280980
    2 references
    ráite i
    PubChem Béarla
    PubChem CID Béarla
    5280980
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    CLAVULANIC ACID (Béarla)
    dáta rochtana
    19 Samhain 2016
    matched by identifier from Béarla
    InChIKey Béarla
    InChIKey Béarla
    HZZVJAQRINQKSD-PBFISZAISA-N
    Reaxys registry number Béarla
    787059
    1 reference
    ráite i
    ChEBI Béarla
    ChEBI ID Béarla
    48947
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    clavulanic acid (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    ChEMBL ID Béarla
    CHEMBL777
    1 reference
    ráite i
    ChEMBL Béarla
    ChEMBL ID Béarla
    CHEMBL777
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    CLAVULANIC ACID (Béarla)
    dáta rochtana
    19 Samhain 2016
    UniChem compound ID Béarla
    307121
    1 reference
    ráite i
    UniChem Béarla
    EC number Béarla
    261-069-2
    1 reference
    ráite i
    Global Substance Registration System Béarla
    UNII Béarla
    23521W1S24
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    clavulanic acid (Béarla)
    dáta rochtana
    19 Samhain 2016
    ECHA Substance Infocard ID Béarla
    100.055.500
    1 reference
    ráite i
    ECHA Substance Infocard database Béarla
    ECHA Substance Infocard ID Béarla
    100.055.500
    dáta rochtana
    27 Nollaig 2018
    teideal
    Clavulanic acid (Béarla)
    quotation Béarla
    CAS no.: 58001-44-8 (Béarla)
    MeSH descriptor ID Béarla
    D019818
    luaite mar
    Clavulanic Acid
    1 reference
    ráite i
    Medical Subject Headings Béarla
    MeSH descriptor ID Béarla
    D019818
    dáta rochtana
    14 Márta 2018
    RxNorm ID Béarla
    21216
    1 reference
    ráite i
    Global Substance Registration System Béarla
    UNII Béarla
    23521W1S24
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    clavulanic acid (Béarla)
    dáta rochtana
    19 Samhain 2016
    48203
    1 reference
    ráite i
    NDF-RT Béarla
    NDF-RT ID Béarla
    N0000147772
    dáta rochtana
    26 Feabhra 2018
    KNApSAcK ID Béarla
    C00018091
    1 reference
    ráite i
    ChEBI Béarla
    ChEBI ID Béarla
    48947
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    clavulanic acid (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    NDF-RT ID Béarla
    Probes And Drugs ID Béarla
    PD009731
    0 references
    DrugCentral ID Béarla
    669
    1 reference
    ráite i
    UniChem Béarla
    KEGG ID Béarla
    D07711
    1 reference
    ráite i
    ChEBI Béarla
    ChEBI ID Béarla
    48947
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    clavulanic acid (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    PDB ligand ID Béarla
    J01
    0 references
    CAB ID Béarla
    60862
    1 reference
    ráite i
    CAB Thesaurus Béarla
    dáta rochtana
    6 Aibreán 2020
    Freebase ID Béarla
    /m/05sxzz
    1 reference
    ráite i
    Freebase Data Dumps Béarla
    dáta foilsithe
    28 Deireadh Fómhair 2013
    Microsoft Academic ID Béarla
    2779454058
    0 references
    PDB structure ID Béarla
    2XH9
    1 reference
    ráite i
    Protein Data Bank Béarla
    PDB structure ID Béarla
    2XH9
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    2XH9 (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    2XF3
    1 reference
    ráite i
    Protein Data Bank Béarla
    PDB structure ID Béarla
    2XF3
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    2XF3 (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    2XFS
    1 reference
    ráite i
    Protein Data Bank Béarla
    PDB structure ID Béarla
    2XFS
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    2XFS (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    2JAP
    1 reference
    ráite i
    Protein Data Bank Béarla
    PDB structure ID Béarla
    2JAP
    teanga an tsaothair nó an ainm
    Béarla
    teideal
    2JAP (Béarla)
    dáta rochtana
    19 Deireadh Fómhair 2016
    UMLS CUI Béarla
     
    cuir in eagar
    cuir in eagar
      cuir in eagar
        cuir in eagar
          cuir in eagar
            cuir in eagar
              cuir in eagar
                cuir in eagar
                  cuir in eagar
                  Aisghafa ó "https://www.wikidata.org/w/index.php?title=Q415709&oldid=2186676834"