Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis (Q41592573)

4 October 2017

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis (English)

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4 October 2017

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4 October 2017

Michal Tomcik

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Gerhard Krönke

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Gerhard Krönke

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Georg Schett

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object named as

Georg Schett

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4 October 2017

Katrin Palumbo-Zerr

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4 October 2017

Pawel Zerr

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4 October 2017

Alfiya Distler

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4 October 2017

Judith Fliehr

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4 October 2017

Rossella Mancuso

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4 October 2017

Jingang Huang

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4 October 2017

Dirk Mielenz

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4 October 2017

Barbara G Fürnrohr

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4 October 2017

Carina Scholtysek

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4 October 2017

Clara Dees

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4 October 2017

Christian Beyer

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4 October 2017

Oliver Distler

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4 October 2017

Jörg H W Distler

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4 October 2017

language of work or name

English

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publication date

12 January 2015

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4 October 2017

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4 October 2017

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4 October 2017

150-158

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https://scigraph.springernature.com/pub.10.1038/nm.3777

4 October 2017

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cites work

Cellular and molecular mechanisms of fibrosis

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TGFβ signalling in context

21 January 2018

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Wound repair and regeneration

21 January 2018

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21 January 2018

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Host responses in tissue repair and fibrosis

21 January 2018

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Activation of pregnane X receptor inhibits experimental dermal fibrosis

21 January 2018

1 reference

Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma

21 January 2018

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Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

21 January 2018

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Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.

21 January 2018

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NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

21 January 2018

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Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

21 January 2018

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The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes

21 January 2018

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Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity

21 January 2018

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Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.

21 January 2018

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The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling.

21 January 2018

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Cytosporone B is an agonist for nuclear orphan receptor Nur77.

21 January 2018

1 reference

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

21 January 2018

1 reference

Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1.

21 January 2018

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Mutations in fibrillin-1 cause congenital scleroderma: stiff skin syndrome

21 January 2018

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Nuclear receptors versus inflammation: mechanisms of transrepression

21 January 2018

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Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth

21 January 2018

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Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells

21 January 2018

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Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma

21 January 2018

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Quantitative and reproducible murine model of excisional wound healing.

21 January 2018

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Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

21 January 2018

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Tyrosine kinase signaling in fibrotic disorders: Translation of basic research to human disease.

21 January 2018

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The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53.

21 January 2018

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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

21 January 2018

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During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

21 January 2018

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A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro

21 January 2018

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Platelet-derived serotonin links vascular disease and tissue fibrosis

21 January 2018

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Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

21 January 2018

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NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.

21 January 2018

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Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.

21 January 2018

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A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

21 January 2018

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Methylation determines fibroblast activation and fibrogenesis in the kidney

21 January 2018

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BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

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Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

21 January 2018

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Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

21 January 2018

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12 December 2020

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex

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12 December 2020

Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice

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12 December 2020

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling

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12 December 2020

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

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12 December 2020

Vitamin D receptor regulates TGF-β signalling in systemic sclerosis

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12 December 2020

Surgical approaches to create murine models of human wound healing

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12 December 2020

Identifiers

DOI

10.1038/NM.3777

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4 October 2017

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