Nucleotide binding oligomerization domain containing 2 (Q416481)

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mammalian protein found in Homo sapiens

• Nod2 Signaling Adaptor Protein
• caspase recruitment domain family, member 15
• nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
• NOD2
• caspase recruitment domain protein 15
• caspase recruitment domain-containing protein 15
• NOD-like receptor C2
• nucleotide-binding oligomerization domain-containing protein 2
• nucleotide-binding oligomerization domain 2
• NLR family, CARD domain containing 2
• inflammatory bowel disease protein 1

edit

Language	Label	Description	Also known as
English	Nucleotide binding oligomerization domain containing 2	mammalian protein found in Homo sapiens	Nod2 Signaling Adaptor Protein caspase recruitment domain family, member 15 nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2 NOD2 caspase recruitment domain protein 15 caspase recruitment domain-containing protein 15 NOD-like receptor C2 nucleotide-binding oligomerization domain-containing protein 2 nucleotide-binding oligomerization domain 2 NLR family, CARD domain containing 2 inflammatory bowel disease protein 1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9HC29

part of

Leucine-rich repeat domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9HC29

Death-like domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9HC29

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9HC29

NACHT nucleoside triphosphatase family

1 reference

based on heuristic

inferred from protein domain or family

CARD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

NOD2 protein.png
1,920 × 975; 597 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9HC29

encoded by

NOD2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9HC29

molecular function

Hsp90 protein binding

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

nucleotide binding

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

Hsp70 protein binding

determination method

IPI

1 reference

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

protein binding

determination method

IPI

20 references

retrieved

1 January 2018

stated in

CLAN, a novel human CED-4-like gene

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

Role for erbin in bacterial activation of Nod2

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

The intermediate filament protein, vimentin, is a regulator of NOD2 activity

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

Evaluation of Nod-like receptor (NLR) effector domain interactions

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

peptidoglycan binding

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

enzyme binding

determination method

IPI

1 reference

retrieved

1 January 2018

stated in

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

actin binding

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

CARD domain binding

determination method

IPI

1 reference

retrieved

1 January 2018

stated in

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

ATP binding

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

protein kinase binding

determination method

IPI

3 references

retrieved

1 January 2018

stated in

Reciprocal cross-talk between Nod2 and TAK1 signaling pathways

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

muramyl dipeptide binding

determination method

IEA

IDA

2 references

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

1 January 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

protein-containing complex binding

determination method

IPI

1 reference

retrieved

1 January 2018

stated in

The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IPI

cell component

cytoplasm

determination method

IDA

TAS

IEA

6 references

retrieved

16 July 2018

stated in

NLRs join TLRs as innate sensors of pathogens

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

TAS

retrieved

16 July 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

16 July 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

16 July 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

16 July 2018

stated in

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

cytosol

determination method

IDA

TAS

3 references

retrieved

16 July 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

TAS

retrieved

16 July 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

16 July 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

vesicle

determination method

IDA

2 references

retrieved

1 January 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

membrane

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

plasma membrane

determination method

IDA

IEA

3 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

1 January 2018

stated in

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

cell surface

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Role for erbin in bacterial activation of Nod2

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

basolateral plasma membrane

determination method

IDA

IEA

2 references

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

1 January 2018

stated in

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

COP9 signalosome

determination method

IDA

1 reference

retrieved

16 July 2018

stated in

The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

cytoskeleton

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

Golgi apparatus

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

mitochondrion

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

protein-containing complex

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

cytoplasm

determination method

IBA

IDA

IEA

TAS

7 references

retrieved

1 January 2018

stated in

NLRs join TLRs as innate sensors of pathogens

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

1 January 2018

stated in

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IBA

cytosol

determination method

IBA

IDA

TAS

4 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

retrieved

1 January 2018

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IBA

biological process

positive regulation of prostaglandin-endoperoxide synthase activity

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

regulation of apoptotic process

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

defense response

determination method

TAS

1 reference

retrieved

1 January 2018

stated in

NLRs join TLRs as innate sensors of pathogens

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

detection of biotic stimulus

determination method

TAS

1 reference

retrieved

1 January 2018

stated in

NLRs join TLRs as innate sensors of pathogens

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

cytokine production involved in immune response

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

positive regulation of cytokine production involved in inflammatory response

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

intracellular signal transduction

determination method

IDA

1 reference

retrieved

16 July 2018

stated in

Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

detection of muramyl dipeptide

determination method

IDA

2 references

retrieved

1 January 2018

stated in

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of interleukin-10 production

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

positive regulation of epithelial cell proliferation

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

immune system process

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

positive regulation of oxidoreductase activity

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

response to muramyl dipeptide

determination method

IDA

IEA

IMP

4 references

retrieved

16 July 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IMP

retrieved

16 July 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

16 July 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

16 July 2018

stated in

Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of prostaglandin-E synthase activity

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

positive regulation of JNK cascade

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of nitric-oxide synthase biosynthetic process

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

positive regulation of NIK/NF-kappaB signaling

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

positive regulation of phosphatidylinositol 3-kinase activity

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

positive regulation of gamma-delta T cell activation

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

cellular response to muramyl dipeptide

determination method

IDA

IMP

3 references

retrieved

1 January 2018

stated in

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

retrieved

1 January 2018

stated in

Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

retrieved

1 January 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

JNK cascade

determination method

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

negative regulation of macrophage apoptotic process

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

positive regulation of dendritic cell antigen processing and presentation

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

nucleotide-binding oligomerization domain containing 2 signaling pathway

determination method

IDA

2 references

retrieved

1 January 2018

stated in

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

maintenance of gastrointestinal epithelium

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

defense response to bacterium

determination method

IDA

1 reference

retrieved

16 July 2018

stated in

Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of NF-kappaB transcription factor activity

determination method

IDA

TAS

IMP

6 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

retrieved

1 January 2018

stated in

A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

retrieved

1 January 2018

stated in

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of interleukin-8 production

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

detection of bacterium

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of interleukin-1 beta production

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

regulation of inflammatory response

determination method

IC

1 reference

retrieved

1 January 2018

stated in

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IC

positive regulation of interleukin-6 production

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

protein complex oligomerization

determination method

TAS

1 reference

retrieved

1 January 2018

stated in

NLRs join TLRs as innate sensors of pathogens

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

positive regulation of tumor necrosis factor production

determination method

IDA

IMP

2 references

retrieved

1 January 2018

stated in

NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

retrieved

1 January 2018

stated in

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of ERK1 and ERK2 cascade

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

IDA

2 references

retrieved

16 July 2018

stated in

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

16 July 2018

stated in

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HC29&geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of B cell activation

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of interleukin-17 production

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

positive regulation of type 2 immune response

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

nucleotide-binding oligomerization domain containing signaling pathway

determination method

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

positive regulation of stress-activated MAPK cascade

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

positive regulation of Notch signaling pathway

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

positive regulation of transcription by RNA polymerase II

determination method

IDA

1 reference

retrieved

1 January 2018

stated in

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

cellular response to organic cyclic compound

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

positive regulation of cell population proliferation

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

innate immune response

determination method

IEA

NAS

IDA

3 references

retrieved

1 January 2018

stated in

The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

NAS

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

1 January 2018

stated in

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

response to nutrient

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

positive regulation of dendritic cell cytokine production

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

positive regulation of protein K63-linked ubiquitination

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

cellular response to peptidoglycan

determination method

IEA

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

positive regulation of MAP kinase activity

determination method

ISS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

ISS

interleukin-1-mediated signaling pathway

determination method

TAS

1 reference

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

TAS

cellular response to lipopolysaccharide

determination method

IMP

1 reference

retrieved

1 January 2018

stated in

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

response to muramyl dipeptide

determination method

IBA

IDA

IEA

IMP

5 references

retrieved

1 January 2018

stated in

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IMP

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IEA

retrieved

1 January 2018

stated in

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IBA

intracellular signal transduction

determination method

IBA

IDA

2 references

retrieved

1 January 2018

stated in

Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IBA

defense response to bacterium

determination method

IBA

IDA

2 references

retrieved

1 January 2018

stated in

Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae

GOA

curator

HUGO Gene Nomenclature Committee

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IBA

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

IBA

IDA

3 references

retrieved

1 January 2018

stated in

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

GOA

curator

UniProt

UniProt protein ID

Q9HC29

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IDA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC29

determination method

IBA

Gene Atlas image

PBB GE NOD2 220066 at fs.png
732 × 530; 10 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q9HC29

1 reference

stated in

Identifiers.org

has part(s)

Leucine-rich repeat

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9HC29

CARD domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9HC29

NACHT nucleoside triphosphatase domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9HC29

Identifiers

MeSH descriptor ID

D053473

subject named as

Nod2 Signaling Adaptor Protein

0 references

MeSH tree code

D12.644.360.024.131.500

0 references

D12.644.360.024.313.500

0 references

D12.644.360.075.358.500

0 references

D12.644.360.539.500.500

0 references

D12.776.157.057.006.500

0 references

D12.776.157.057.078.500

0 references

D12.776.476.024.139.500

0 references

D12.776.476.024.391.500

0 references

D12.776.476.075.358.500

0 references

RefSeq protein ID

NP_001280486

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

NP_071445

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_006721305

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_006721306

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_011521561

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_011521562

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_011521563

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_016879024

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_016879025

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_016879026

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

XP_016879027

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

NP_001357395

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

64127

UniProt protein ID

Q9HC29

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9HC29

Ensembl protein ID

ENSP00000300589

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000300589

ENSP00000431681

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000431681

ENSP00000435149

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000435149

ENSP00000437246

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000437246

ENSP00000462443

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000462443

ENSP00000463145

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000463145

ENSP00000463423

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000463423

ENSP00000464065

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000464065

ENSP00000493088

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000493088

ENSP00000495993

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000495993

ENSP00000496533

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000496533

Freebase ID

/m/02qmhy_

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

7573103

0 references

171044643

0 references

OpenAlex ID

C7573103

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

5IRL

found in taxon

European Rabbit

0 references

5IRM

found in taxon

European Rabbit

0 references

5IRN

found in taxon

European Rabbit

0 references

UMLS CUI

C1720989

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(12 entries)

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• bswiki NOD2
• cawiki NOD2
• dewiki NOD2
• enwiki NOD2
• eswiki NOD2
• fawiki NOD2
• frwiki NOD2
• plwiki NOD2
• ptwiki NOD2
• ruwiki NOD2
• ttwiki NOD2
• ukwiki NOD2

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q416481&oldid=2022901664"