Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ. (Q41678523)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

0 references

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

Natasha Dubois Cauwelaert

22 February 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Mark T Orr

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Malcolm Duthie

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

9

Steven G Reed

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author name string

Anthony L Desbien

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Steven J Reed

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Hilton R Bailor

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

John D Laurance

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

Christopher B Fox

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

language of work or name

English

0 references

publication date

3 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

European Journal of Immunology

22 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

45

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

page(s)

407-417

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

How do adjuvants work? Important considerations for new generation adjuvants

22 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Towards an understanding of the adjuvant action of aluminium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

The mechanism of action of MF59 - an innately attractive adjuvant formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Role of adjuvants in modeling the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

A synthetic adjuvant to enhance and expand immune responses to influenza vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

A synthetic TLR4 agonist formulated in an emulsion enhances humoral and Type 1 cellular immune responses against GMZ2--a GLURP-MSP3 fusion protein malaria vaccine candidate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Molecular and cellular signatures of human vaccine adjuvants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

The inflammasome NLRs in immunity, inflammation, and associated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Molecular mechanisms involved in inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Defective NK cell activity and Th1 response in IL-18-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Protection of mice from Mycobacterium tuberculosis by ID87/GLA-SE, a novel tuberculosis subunit vaccine candidate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Type I interferon-mediated stimulation of T cells by CpG DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Revisiting caspase-11 function in host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Pathogen recognition and inflammatory signaling in innate immune defenses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Programming the magnitude and persistence of antibody responses with innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Poly's plea: membership to the club of APCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Neutrophils efficiently cross-prime naive T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Neutrophil function in inflammation and inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Non-canonical inflammasome activation targets caspase-11

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

In vitro evaluation of TLR4 agonist activity: formulation effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

SPICE: exploration and analysis of post-cytometric complex multivariate datasets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

NIH Image to ImageJ: 25 years of image analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

7 January 2021

Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

7 January 2021

Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

7 January 2021

Inflammatory caspases are innate immune receptors for intracellular LPS.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201444543

7 January 2021

Identifiers

DOI

10.1002/EJI.201444543

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25367751%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference