Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes? (Q41679671)

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scientific article published on 26 September 2008

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English	Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes?	scientific article published on 26 September 2008

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

Challenging current paradigms related to cardiomyopathies. Are changes in the Ca2+ sensitivity of myofilaments containing cardiac troponin C mutations (G159D and L29Q) good predictors of the phenotypic outcomes? (English)

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

author name string

David Dweck

1

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

Nir Hus

2

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

James D Potter

3

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

language of work or name

0 references

publication date

26 September 2008

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

283

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

48

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

33119-33128

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Mutations in the cardiac Troponin C gene are a cause of idiopathic dilated cardiomyopathy in childhood.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Structural based insights into the role of troponin in cardiac muscle pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Molecular and cellular aspects of troponin cardiomyopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Molecular mechanisms of inherited cardiomyopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Regulation of contraction in striated muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Phosphorylation of both serine residues in cardiac troponin I is required to decrease the Ca2+ affinity of cardiac troponin C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

A fluorescent probe study of Ca2+ binding to the Ca2+-specific sites of cardiac troponin and troponin C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

The role of troponin C in the length dependence of Ca(2+)-sensitive force of mammalian skeletal and cardiac muscles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

The calcium and magnesium binding sites on troponin and their role in the regulation of myofibrillar adenosine triphosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Cardiac Myosin from Pig Heart Ventricle. Purification and Enzymatic Properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

6 June 2018

Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Structural kinetics of cardiac troponin C mutants linked to familial hypertrophic and dilated cardiomyopathy in troponin complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Expanding the range of free calcium regulation in biological solutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

A mutation in the N-terminus of troponin I that is associated with hypertrophic cardiomyopathy affects the Ca(2+)-sensitivity, phosphorylation kinetics and proteolytic susceptibility of troponin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Normalization for body size and population-attributable risk of left ventricular hypertrophy: the Strong Heart Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Preparation of troponin and its subunits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2586272

18 August 2018

Diffusion in two-component lipid membranes--a fluorescence correlation spectroscopy and monte carlo simulation study

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804070200

21 January 2018

Purification of muscle actin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+- and Sr2+-sensitivity of the ATPase activity of rabbit skeletal myofibrils: effect of the complete substitution of troponin C with cardiac troponin C, calmodulin, and parvalbumins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of association and of positive inotropic drugs on calcium binding to cardiac troponin C

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of rigor and cycling cross-bridges on the structure of troponin C and on the Ca2+ affinity of the Ca2+-specific regulatory sites in skinned rabbit psoas fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the four Ca2+ binding sites of troponin C in the regulation of skeletal muscle contraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+ sensitivity and tropomyosin N-domain flexibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial hypertrophic cardiomyopathy mutations from different functional regions of troponin T result in different effects on the pH and Ca2+ sensitivity of cardiac muscle contraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The purification of cardiac myofibrils with Triton X-100

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of cardiac troponin C function by the cardiac-specific N-terminus of troponin I: influence of PKA phosphorylation and involvement in cardiomyopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820258

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M804070200

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

7 October 2017

ResearchGate publication ID

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