Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation (Q41689014)

7 October 2017

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title

Effects of the immunosuppressive drugs CsA and FK506 on intracellular signalling and gene regulation (English)

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7 October 2017

Rühlmann A

1

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7 October 2017

Nordheim A

series ordinal

2

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7 October 2017

language of work or name

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1 December 1997

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7 October 2017

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7 October 2017

198

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7 October 2017

192-206

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7 October 2017

1-3

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Biological effects of cyclosporin A: A new antilymphocytic agent

7 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

FK-506 enters the clinic

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

NFATp, a cyclosporin-sensitive transcription factor implicated in cytokine gene induction.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Nuclear factor of activated T cells contains Fos and Jun.

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin-sensitive expression of cytokine mRNA in mouse macrophages responding to bacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A.

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Activation of nuclear factor of activated T cells in a cyclosporin A-resistant pathway

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells. Convergence of costimulatory signals and differences from transformed T cells

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

JNK is involved in signal integration during costimulation of T lymphocytes.

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

A putative sirolimus (rapamycin) effector protein

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Complementary DNA for human T-cell cyclophilin.

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

A cyclophilin-related protein involved in the function of natural killer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Evidence for a functional receptor for cyclosporin A on the surface of lymphocytes

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Interleukin-8 is a cyclosporin A binding protein

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Molecular cloning and overexpression of the human FK506-binding protein FKBP

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

The human erythrocyte membrane contains a novel 12-kDa inositolphosphate-binding protein that is an immunophilin

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Protein kinase C deficiency blocks recovery from agonist-induced desensitization

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A inhibits CD40 ligand expression in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Induction of c-ets and c-fos gene expression upon antigenic stimulation of a T cell hybridoma with inducible cytolytic capacity

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Induction of members of the IL-8/NAP-1 gene family in human T lymphocytes is suppressed by cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Regulation of gene expression in lectin-stimulated or lymphokine-stimulated T lymphocytes. Effects of cyclosporine

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Evidence that cyclosporine inhibits cell-mediated immunity primarily at the level of the T lymphocyte rather than the accessory cell

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Expression of leucocyte chemoattractants by interstitial renal fibroblasts: up-regulation by drugs associated with interstitial fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A sensitivity of the NF-kappa B site of the IL2R alpha promoter in untransformed murine T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Physiologic signaling in normal human T-cells: mRNA phenotyping by northern blot analysis and reverse transcription-polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Complex regulation of the T cell receptor alpha gene: three different modes of triggering induction

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Regulated expression of telomerase activity in human T lymphocyte development and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Expression of novel-transposon-containing mRNAs in human T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Calcium-mediated inhibition of phorbol ester and Tax trans-activation of the human T cell leukaemia virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Induction, suppression and superinduction of lymphokine mRNA in T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

An activation-dependent, T-lymphocyte-specific transcriptional activator in the mouse mammary tumor virus env gene

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Tumor necrosis factor-alpha up-regulates Bcl-2 expression and decreases calcium-dependent apoptosis in human B cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A enhances cytokine and phorbol ester-induced fibroblast collagenase expression

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporine A regulates T cell-epithelial cell adhesion by altering LFA-1 and ICAM-1 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A enhances the calcium-dependent induction of AP-1 complex and c-fos mRNA in a T cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Unexpected up-regulation of gene expression by cyclosporin A and FK-506 in a T-cell lymphoma: Both immunosuppressants augment Ly-6E antigen induction by interferon-γ in the presence of ionomycin

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Down-regulation of lck mRNA by T cell activation involves transcriptional and post-transcriptional mechanisms

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https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Cyclosporin A inhibits the decrease of CD4/CD8 expression induced by protein kinase C activation

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Calcineurin inhibition of dynamin I GTPase activity coupled to nerve terminal depolarization

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Ca2+ x calmodulin prevents myristoylated alanine-rich kinase C substrate protein phosphorylation by protein kinase Cs in C6 rat glioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Identification of soluble protein phosphatases that dephosphorylate voltage-sensitive sodium channels in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

Compromised mitochondrial function results in dephosphorylation of tau through a calcium-dependent process in rat brain cerebral cortical slices.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2897%2980040-X

7 January 2021

10.1016/S0171-2985(97)80040-X

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