Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas (Q41710355)

7 October 2017

title

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas (English)

1 reference

7 October 2017

Jau-Yu Liau

3

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Jen-Chieh Lee

object named as

Jen-Chieh Lee

1

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Ching-yao Yang

object named as

Ching-Yao Yang

6

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Yung-Ming Jeng

object named as

Yung-Ming Jeng

2

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author name string

Jia-Huei Tsai

4

1 reference

7 October 2017

Hung-Han Hsu

5

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7 October 2017

language of work or name

1 reference

29 May 2015

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7 October 2017

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7 October 2017

volume

28

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7 October 2017

issue

8

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7 October 2017

page(s)

1064-1073

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HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.

7 October 2017

cites work

1 reference

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Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)

21 January 2018

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Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

21 January 2018

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Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: a report of the CHAMP Study Group. Chromosomes and MorPhology.

21 January 2018

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Distinct chromosomal imbalances in pleomorphic and in high-grade dedifferentiated liposarcomas

21 January 2018

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Comparative genomic hybridization study of paraffin-embedded dedifferentiated liposarcoma fixed with Holland Bouin's fluid

21 January 2018

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The role of telomeres in stem cells and cancer

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TERT promoter mutations in familial and sporadic melanoma

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Highly recurrent TERT promoter mutations in human melanoma

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Telomere recombination and alternative telomere lengthening mechanisms

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Telomere length maintenance--an ALTernative mechanism.

21 January 2018

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Alternative lengthening of telomeres: models, mechanisms and implications

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Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.

21 January 2018

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Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors

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Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

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The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas

21 January 2018

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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

21 January 2018

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The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

21 January 2018

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Distinct factors control histone variant H3.3 localization at specific genomic regions

21 January 2018

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ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

21 January 2018

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TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

21 January 2018

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Multiple mechanisms of telomere maintenance exist in liposarcomas.

21 January 2018

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ALT-associated promyelocytic leukaemia body (APB) detection as a reproducible tool to assess alternative lengthening of telomere stability in liposarcomas

21 January 2018

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Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis.

21 January 2018

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Dedifferentiated liposarcoma with homologous lipoblastic differentiation: expanding the spectrum to include low-grade tumours.

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Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years.

21 January 2018

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Leiomyosarcoma with alternative lengthening of telomeres is associated with aggressive histologic features, loss of ATRX expression, and poor clinical outcome.

21 January 2018

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The role of genetic testing in soft tissue sarcoma

21 January 2018

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Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma

21 January 2018

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Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramatically

21 January 2018

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Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.

21 January 2018

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Telomere Maintenance Mechanisms in Liposarcomas: Association with Histologic Subtypes and Disease Progression

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26022452

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26022452

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26022452

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MODPATHOL.2015.67

1 reference

Dimensions Publication ID

7 October 2017

1040025838

0 references

1 reference