Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration. (Q41721009)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25270258%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration (English)

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20 February 2020

19

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20 February 2020

Oliver Sieber

21

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20 February 2020

Toby J Phesse

1

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20 February 2020

Dustin J Flanagan

4

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20 February 2020

Cameron Nowell

9

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20 February 2020

Robert N Jorissen

10

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20 February 2020

Chin Wee Tan

11

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20 February 2020

Ashleigh R Poh

14

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20 February 2020

Helen B Pearson

16

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20 February 2020

Robert G. Ramsay

20

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20 February 2020

Matthias Ernst

25

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20 February 2020

author name string

Michael Buchert

2

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20 February 2020

Emma Stuart

3

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20 February 2020

Maree Faux

5

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20 February 2020

Shoukat Afshar-Sterle

6

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20 February 2020

Francesca Walker

7

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20 February 2020

Hui-Hua Zhang

8

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20 February 2020

Yumiko Hirokawa

12

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20 February 2020

Moritz F Eissmann

13

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20 February 2020

Jordane Malaterre

15

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20 February 2020

David G Kirsch

17

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20 February 2020

Paolo Provero

18

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20 February 2020

Antony W Burgess

22

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20 February 2020

Dennis Huszar

23

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20 February 2020

Elizabeth Vincan

24

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20 February 2020

publication date

30 September 2014

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20 February 2020

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20 February 2020

volume

7

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20 February 2020

issue

345

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page(s)

ra92

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The intestinal crypt, a prototype stem cell compartment

20 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Wnt/β-catenin signaling and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Myc deletion rescues Apc deficiency in the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Modelling Myc inhibition as a cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Expression of p-STAT3 in human colorectal adenocarcinoma and adenoma; correlation with clinicopathological factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Deficiency of Mbd2 attenuates Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Crypt stem cells as the cells-of-origin of intestinal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

STATs in cancer inflammation and immunity: a leading role for STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Prediction and experimental validation of novel STAT3 target genes in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Identification of novel direct Stat3 target genes for control of growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Mutational switch of an IL-6 response to an interferon-gamma-like response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Histological demonstration of mucin after periodic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

The Paneth cell: a source of intestinal lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Genome-wide discovery of functional transcription factor binding sites by comparative genomics: the case of Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Overexpression of BMI-1 is associated with poor prognosis in cervical cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Bmi-1 promotes the chemoresistance, invasion and tumorigenesis of pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Polycomb group protein Bmi1 expression in colon cancers predicts the survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Bmi1 is expressed in vivo in intestinal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

A phase II study of RO4929097 in metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Development of PI3K inhibitors: lessons learned from early clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005411

10.1126/SCISIGNAL.2005411

21 January 2018

Identifiers

DOI

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20 February 2020

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