Structure and function of the insulin-like growth factor I receptor (Q41727239)

8 October 2017

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title

Structure and function of the insulin-like growth factor I receptor (English)

1 reference

8 October 2017

Sepp-Lorenzino L

1

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PubMed ID

9516079

8 October 2017

language of work or name

English

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publication date

1 February 1998

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Breast Cancer Research and Treatment

8 October 2017

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8 October 2017

47

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8 October 2017

3

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8 October 2017

235-253

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https://scigraph.springernature.com/pub.10.1023/a:1005955017615

8 October 2017

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Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

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Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor

21 January 2018

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Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene.

21 January 2018

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Developmental regulation of the rat insulin-like growth factor I receptor gene

21 January 2018

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Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II.

21 January 2018

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Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding

21 January 2018

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Pituitary and hypothalamic insulin-like growth factor-I (IGF-I) and IGF-I receptor expression in food-deprived rats.

21 January 2018

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Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens.

21 January 2018

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The role of the insulin-like growth factor-I receptor in cancer

21 January 2018

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In vivo regulation of granulosa cell somatomedin-C/insulin-like growth factor I receptors

21 January 2018

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Progestin regulation of insulin and insulin-like growth factor I receptors in cultured human breast cancer cells

21 January 2018

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Regulation of the genes for insulin-like growth factor (IGF) I and II and their receptors by steroids and gonadotropins in the ovary.

21 January 2018

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Expression of receptors for epidermal growth factor and insulin-like growth factor I by ZR-75-1 human breast cancer cell variants is inversely related: the effect of steroid hormones on insulin-like growth factor I receptor expression

21 January 2018

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Type I insulin-like growth factor receptor gene expression in normal human breast tissue treated with oestrogen and progesterone

21 January 2018

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Differential regulation of insulin-like growth factor-I (IGF-I) receptor gene expression by IGF-I and basic fibroblastic growth factor

21 January 2018

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Fibroblast Growth Factor Inhibits Insulin-Like Growth Factor-II (IGF-II) Gene Expression and Increases IGF-I Receptor Abundance in BC3H-1 Muscle Cells

21 January 2018

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Constitutively expressed c-myb abrogates the requirement for insulinlike growth factor 1 in 3T3 fibroblasts

21 January 2018

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Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

21 January 2018

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The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor

21 January 2018

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Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

21 January 2018

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Structure and function of a human insulin-like growth factor-I gene promoter

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The regulation of IGF-I receptor gene expression.

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Cloning and Characterization of the Human Insulin-Like Growth Factor-I Receptor Gene 5′-Flanking Region

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Changing the insulin receptor to possess insulin-like growth factor I ligand specificity

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two beta subunits are derived from differences in glycosylation.

21 January 2018

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Receptors for insulin-like growth factors in the central nervous system: structure and function.

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Distinct beta-subunits are present in hybrid insulin-like-growth-factor-1 receptors in the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Comparison of insulin and insulin-like growth factor I receptors from rat skeletal muscle and L-6 myocytes

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Hybrid and atypical insulin/insulin-like growth factor I receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The IRS-1 signaling system

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Insulin signal transduction and the IRS proteins

21 January 2018

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Signal transduction mechanism of insulin and insulin-like growth factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Role of IRS-2 in insulin and cytokine signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The GRB family of SH2 domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Involvement of Src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: studies of the domains involved using the yeast two-hybrid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Single tyrosine substitution in the insulin-like growth factor I receptor inhibits ligand-induced receptor autophosphorylation and internalization, but not mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Effects and Binding of Insulin-Like Growth Factor I in the Isolated Soleus Muscle of Lean and Obese Mice: Comparison with Insulin*

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Tyrosine kinase activity of a chimeric insulin-like-growth-factor-1 receptor containing the insulin receptor C-terminal domain. Comparison with the tyrosine kinase activities of the insulin and insulin-like-growth-factor-1 receptors using a cell-fre

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Mutation of a conserved amino acid residue (tryptophan 1173) in the tyrosine kinase domain of the IGF-I receptor abolishes autophosphorylation but does not eliminate biologic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

cDNA Cloning of the Rat IGF I Receptor: Structural Analysis of Rat and Human IGF I and Insulin Receptors Reveals Differences in Alternative Splicing and Receptor-Specific Domain Conservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

Evidence for two insulin-like growth factor I receptors with distinct primary structure that are differentially expressed during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

The role of the insulin-like growth factor system in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

The role of the IGF-I receptor in apoptosis.

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Roles for mannose-6-phosphate receptors in lysosomal enzyme sorting, IGF-II binding and clathrin-coat assembly

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

In-vivo regulation of messenger RNA encoding insulin-like growth factor-I (IGF-I) and its receptor by diabetes, insulin and IGF-I in rat muscle

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Hormonal regulation of type I insulin-like growth factor receptors of Leydig cells in hypophysectomized rats

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Paradoxical effects of overexpression of the type I insulin-like growth factor (IGF) receptor on the responsiveness of human breast cancer cells to IGFs and estradiol

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Thyroid hormone controls the expression of insulin-like growth factor I receptor gene at different levels in lung and heart of developing and adult rats

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Transcriptional regulation of the insulin-like growth factor-I receptor gene: evidence for protein kinase C-dependent and -independent pathways

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states.

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Analysis of the human type I insulin-like growth factor receptor promoter region

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

The regulation of IGF-I receptor gene expression by positive and negative zinc-finger transcription factors

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor

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7 January 2021

Expression and distribution of IGF-1 receptors containing a beta-subunit variant (betagc) in developing neurons.

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Up-regulation of insulin/insulin-like growth factor-I hybrid receptors during differentiation of HT29-D4 human colonic carcinoma cells

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https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Insulin-like growth factor I receptor activated by a transmembrane mutation

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Evidence that receptor aggregation may play a role in transmembrane signaling through the insulin-like growth factor-I receptor

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Functional properties of an isolated alpha beta heterodimeric human placenta insulin-like growth factor 1 receptor complex

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Intramolecular subunit interactions between insulin and insulin-like growth factor 1 alpha beta half-receptors induced by ligand and Mn/MgATP binding

1 reference

https://api.crossref.org/works/10.1023%2FA%3A1005955017615

7 January 2021

Identifiers

DOI

10.1023/A:1005955017615

1 reference

PubMed ID

9516079

Dimensions Publication ID

8 October 2017

0 references

1 reference

PubMed ID

9516079