Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. (Q41728302)

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10 November 2019

review article

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title

Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes (English)

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10 November 2019

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1

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10 November 2019

author name string

T A Steitz

series ordinal

2

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10 November 2019

publication date

1 February 1998

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Current Opinion in Structural Biology

10 November 2019

published in

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10 November 2019

volume

8

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10 November 2019

issue

1

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10 November 2019

page(s)

54-63

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Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69

10 November 2019

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Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution

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Structure of Taq polymerase with DNA at the polymerase active site

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Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

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A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity.

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A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta

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Compilation and alignment of DNA polymerase sequences

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Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions

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Structure of DNA polymerase I Klenow fragment bound to duplex DNA

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Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

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Functional consequences and exonuclease kinetic parameters of point mutations in bacteriophage T4 DNA polymerase

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Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

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Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp

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The carboxyl terminus of the bacteriophage T4 DNA polymerase is required for holoenzyme complex formation

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An attempt to unify the structure of polymerases

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

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Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

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Crystal structure of Thermus aquaticus DNA polymerase

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Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability

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7 January 2021

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

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7 January 2021

DNA polymerase beta belongs to an ancient nucleotidyltransferase superfamily

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

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The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

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Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase

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A unified polymerase mechanism for nonhomologous DNA and RNA polymerases

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Polymerase structures and mechanism.

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DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

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The thioredoxin binding domain of bacteriophage T7 DNA polymerase confers processivity on Escherichia coli DNA polymerase I

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Molecular mechanisms of manganese mutagenesis

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Induction of mutations in bacteriophage T4 with divalent manganese

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On the fidelity of DNA replication: manganese mutagenesis in vitro.

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Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

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7 January 2021

Elementary steps in the DNA polymerase I reaction pathway

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Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

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Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

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Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9519297%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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