The TH1/TH2 paradigm in allergy (Q41733405)

8 October 2017

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title

The TH1/TH2 paradigm in allergy (English)

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8 October 2017

Maggi E

1

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8 October 2017

1 January 1998

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Immunotechnology : an international journal of immunological engineering

8 October 2017

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8 October 2017

3

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8 October 2017

233-244

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8 October 2017

4

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Regulation of the development of type 2 T-helper cells in allergy

8 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Biology of human TH1 and TH2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Lymphokine production by human T cells in disease states

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Acquisition of lymphokine-producing phenotype by CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Functional subsets of allergen-reactive human CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Human TH1 and TH2 subsets: doubt no more

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

LAG-3, a novel lymphocyte activation gene closely related to CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Expression and release of LAG-3-encoded protein by human CD4+ T cells are associated with IFN-gamma production .

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

CD8+ T lymphocytes provide helper activity for IgE synthesis in human immunodeficiency virus-infected patients with hyper-IgE.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

T lymphocytes from the normal human peritoneum contain high frequencies of Th2-type CD8+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Ability of HIV to promote a TH1 to TH0 shift and to replicate preferentially in TH2 and TH0 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

CD30 expression by CD8+ T cells producing type 2 helper cytokines. Evidence for large numbers of CD8+CD30+ T cell clones in human immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma

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https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

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https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways

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https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

The function of costimulatory molecules and the development of IL-4-producing T cells

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https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

CD30-mediated signaling promotes the development of human T helper type 2-like T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

TH1 and TH2 cell antigen receptors in experimental leishmaniasis

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Immunosuppression by Fc region-mismatched anti-T cell antibody treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin 4 is localized to and released by human mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

CD1 recognition by mouse NK1+ T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5- producing effector cells

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Development in vitro of human CD4+ thymocytes into functionally mature Th2 cells. Exogenous interleukin-12 is required for priming thymocytes to produce both Th1 cytokines and interleukin-10

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Aberrant interleukin (IL)-4 and IL-5 production in vitro by CD4+ helper T cells from atopic subjects

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Abnormal production of T helper 2 cytokines interleukin-4 and interleukin-5 by T cells from newborns with atopic parents

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppres

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Genetic linkage of T-cell receptor alpha/delta complex to specific IgE responses

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Transcription of the interleukin 4 gene is regulated by multiple promoter elements

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Abnormal IL-4 gene expression by atopic dermatitis T lymphocytes is reflected in altered nuclear protein interactions with IL-4 transcriptional regulatory element

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Genetic immunization is a simple method for eliciting an immune response

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

Th1 and Th2 T-helper cells exert opposite regulatory effects on procoagulant activity and tissue factor production by human monocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1380-2933%2897%2910005-7

7 January 2021

10.1016/S1380-2933(97)10005-7

Identifiers

DOI

1 reference

8 October 2017

1 reference

PubMed ID

9530557