Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis (Q41755840)

8 October 2017

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title

Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis (English)

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8 October 2017

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Hofker MH

1

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PubMed ID

9568731

8 October 2017

van Vlijmen BJ

series ordinal

2

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PubMed ID

9568731

8 October 2017

Havekes LM

series ordinal

3

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8 October 2017

1 March 1998

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8 October 2017

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8 October 2017

137

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8 October 2017

1

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8 October 2017

1-11

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Apolipoprotein E as a risk factor for coronary heart disease: a genetic and molecular biology approach.

8 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Apolipoprotein E*3-Leiden allele results from a partial gene duplication in exon 4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Type III hyperlipoproteinemia associated with apolipoprotein E deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene cluster: structure and genetic variability in inbred mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse apolipoprotein e-c1-c2 gene cluster.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Comparison of atherosclerotic lesions and HDL-lipid levels in male, female, and testosterone-treated female mice from strains C57BL/6, BALB/c, and C3H.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Evolutionary duplication of a hepatic control region in the human apolipoprotein E gene locus. Identification of a second region that confers high level and liver-specific expression of the human apolipoprotein E gene in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein Cl

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

A mouse model with features of familial combined hyperlipidemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Inactivation of Apoe and Apoc1 by two consecutive rounds of gene targeting: effects on mRNA expression levels of gene cluster members

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Effect of human apoE4 on the clearance of chylomicron-like lipid emulsions and atherogenesis in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Apolipoprotein E deficiency leads to cutaneous foam cell formation in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Phenotypic correction of hypercholesterolemia in apoE-deficient mice by adenovirus-mediated in vivo gene transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Assessment of recombinant adenoviral vectors for hepatic gene therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0021-9150%2897%2900266-9

10.1016/S0021-9150(97)00266-9

7 January 2021

Identifiers

DOI

1 reference

8 October 2017

1 reference

PubMed ID

9568731