Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus. (Q41788681)

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scientific article published on 9 April 2012

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English	Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus.	scientific article published on 9 April 2012

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22491694%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Alanyl-phosphatidylglycerol and lysyl-phosphatidylglycerol are translocated by the same MprF flippases and have similar capacities to protect against the antibiotic daptomycin in Staphylococcus aureus (English)

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28 January 2020

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Staphylococcus aureus

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inferred from title

Christoph M Ernst

3

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28 January 2020

Andreas Peschel

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Andreas Peschel

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28 January 2020

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Christoph J Slavetinsky

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28 January 2020

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9 April 2012

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28 January 2020

Antimicrobial Agents and Chemotherapy

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28 January 2020

56

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28 January 2020

7

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28 January 2020

3492-3497

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28 January 2020

Resistance phenotypes mediated by aminoacyl-phosphatidylglycerol synthases

1 reference

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Reduction in membrane phosphatidylglycerol content leads to daptomycin resistance in Bacillus subtilis

1 reference

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6 June 2018

Multiple peptide resistance factor (MprF)-mediated Resistance of Staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl-phosphatidylglycerol.

1 reference

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Alanyl-phosphatidylglycerol synthase: mechanism of substrate recognition during tRNA-dependent lipid modification in Pseudomonas aeruginosa

1 reference

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Broad-spectrum antimicrobial peptide resistance by MprF-mediated aminoacylation and flipping of phospholipids

1 reference

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Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms

1 reference

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The bacterial defensin resistance protein MprF consists of separable domains for lipid lysinylation and antimicrobial peptide repulsion

1 reference

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Broad range amino acid specificity of RNA-dependent lipid remodeling by multiple peptide resistance factors

1 reference

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The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides

1 reference

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TOPCONS: consensus prediction of membrane protein topology

1 reference

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Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus

1 reference

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Daptomycin: mechanisms of action and resistance, and biosynthetic engineering.

1 reference

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6 June 2018

Genetic analysis of factors affecting susceptibility of Bacillus subtilis to daptomycin

1 reference

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Lantibiotics: mode of action, biosynthesis and bioengineering

1 reference

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6 June 2018

The Bacillus anthracis protein MprF is required for synthesis of lysylphosphatidylglycerols and for resistance to cationic antimicrobial peptides

1 reference

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Staphylococcus aureus evasion of innate antimicrobial defense

1 reference

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6 June 2018

RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393434

6 June 2018

The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393434

6 June 2018

Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393434

6 June 2018

Perspectives on Daptomycin resistance, with emphasis on resistance in Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393434

6 June 2018

Antimicrobial peptide resistance mechanisms of human bacterial pathogens.

1 reference

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6 June 2018

Reduced content of lysyl-phosphatidylglycerol in the cytoplasmic membrane affects susceptibility to moenomycin, as well as vancomycin, gentamicin, and antimicrobial peptides, in Staphylococcus aureus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393434

6 June 2018

MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance.

1 reference

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Bacterial Resistance to Antimicrobial Host Defenses - An Emerging Target for Novel Antiinfective Strategies?

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

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Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine

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Adaptation of Pseudomonas aeruginosa to various conditions includes tRNA-dependent formation of alanyl-phosphatidylglycerol.

1 reference

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1 reference

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1 reference

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Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus

1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Changing the phospholipid composition ofStaphylococcus aureuscauses distinct changes in membrane proteome and membrane-sensory regulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/22491694

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/AAC.00370-12

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22491694%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22491694%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22491694%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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