Novel agents to inhibit microbial virulence and pathogenicity (Q37780752)

23 August 2017

Novel agents to inhibit microbial virulence and pathogenicity (English)

1 reference

23 August 2017

Sonia Escaich

1

1 reference

PubMed ID

20718591

23 August 2017

language of work or name

English

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publication date

1 October 2010

1 reference

Expert Opinion on Therapeutic Patents

23 August 2017

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23 August 2017

20

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23 August 2017

10

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23 August 2017

1401-1418

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Has the era of untreatable infections arrived?

23 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Resistance to antibiotics: are we in the post-antibiotic era?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

What is in the pipeline for Gram-negative pathogens?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

The biology and future prospects of antivirulence therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Antivirulence as a new antibacterial approach for chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Targeting virulence for antibacterial chemotherapy: identifying and characterising virulence factors for lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Targeting virulence: a new paradigm for antimicrobial therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Large-scale identification of genes required for full virulence of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Functional genomics in antibacterial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Genomic approaches to understanding bacterial virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Discovery of virulence factors of pathogenic bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Staphylococcus quorum sensing in biofilm formation and infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Quorum sensing and social networking in the microbial world.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Quorum sensing inhibitors: a patent overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibitors and antagonists of bacterial quorum sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Targeting QseC signaling and virulence for antibiotic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibitors of pathogen intercellular signals as selective anti-infective compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Identity and effects of quorum-sensing inhibitors produced by Penicillium species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Microbial quorum sensing: a tool or a target for antimicrobial therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Staphylococcus aureus--probing for host weakness?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Infection control by antibody disruption of bacterial quorum sensing signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Reduced susceptibility of Staphylococcus aureus to vancomycin and platelet microbicidal protein correlates with defective autolysis and loss of accessory gene regulator (agr) function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Generation of virulence factor variants in Staphylococcus aureus biofilms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Virstatin inhibits dimerization of the transcriptional activator ToxT

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Control of gene expression by type III secretory activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Protein delivery into eukaryotic cells by type III secretion machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Antivirulence drugs to target bacterial secretion systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Targeting type III secretion in Yersinia pestis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Salicylidene acylhydrazides that affect type III protein secretion in Salmonella enterica serovar typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Tethered thiazolidinone dimers as inhibitors of the bacterial type III secretion system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

An inhibitor of gram-negative bacterial virulence protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Sortase as a target of anti-infective therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Discovery of diarylacrylonitriles as a novel series of small molecule sortase A inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Activation of Inhibitors by Sortase Triggers Irreversible Modification of the Active Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Siderophore-based iron acquisition and pathogen control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Cationic host defense (antimicrobial) peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Selective killing of nonreplicating mycobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Lipopolysaccharide (Endotoxin)-host defense antibacterial peptides interactions: role in bacterial resistance and prevention of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

A heptosyltransferase mutant of Pasteurella multocida produces a truncated lipopolysaccharide structure and is attenuated in virulence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Lipopolysaccharide endotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Antibacterial peptides: basic facts and emerging concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

A continuum of anionic charge: structures and functions of D-alanyl-teichoic acids in gram-positive bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Alanine esters of enterococcal lipoteichoic acid play a role in biofilm formation and resistance to antimicrobial peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.511176

10.1517/13543776.2010.511176

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

20718591