Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma (Q41789272)

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scientific article published on May 2011

Language	Label	Description	Also known as
English	Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma	scientific article published on May 2011

Statements

scholarly article

1 reference

Europe PubMed Central

10 October 2017

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma (English)

1 reference

Europe PubMed Central

10 October 2017

Daniel S Lorrain

7

object named as

Daniel S Lorrain

1 reference

Europe PubMed Central

10 October 2017

author name string

Flavia V Castelino

1

1 reference

Europe PubMed Central

10 October 2017

Jon Seiders

2

1 reference

Europe PubMed Central

10 October 2017

Gretchen Bain

3

1 reference

Europe PubMed Central

10 October 2017

Sarah F Brooks

4

1 reference

Europe PubMed Central

10 October 2017

Christopher D King

5

1 reference

Europe PubMed Central

10 October 2017

James S Swaney

6

1 reference

Europe PubMed Central

10 October 2017

Jerold Chun

8

1 reference

Europe PubMed Central

10 October 2017

Andrew D Luster

9

1 reference

Europe PubMed Central

10 October 2017

Andrew M Tager

10

1 reference

Europe PubMed Central

10 October 2017

publication date

1 May 2011

1 reference

Europe PubMed Central

10 October 2017

Arthritis & Rheumatology

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Europe PubMed Central

10 October 2017

63

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Europe PubMed Central

10 October 2017

5

1 reference

Europe PubMed Central

10 October 2017

1405-1415

1 reference

Europe PubMed Central

10 October 2017

LPA receptors: subtypes and biological actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Molecular subsets in the gene expression signatures of scleroderma skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

In perspective: murine models of scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

How does endothelial cell injury start? The role of endothelin in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Formation and function of the myofibroblast during tissue repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Smad transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Scleroderma: from cell and molecular mechanisms to disease models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Production of lysophosphatidic acid in blister fluid: involvement of a lysophospholipase D activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Tissue repair, contraction, and the myofibroblast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Systemic and cell type-specific gene expression patterns in scleroderma skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Regulation of wound healing by growth factors and cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Making sense of latent TGFbeta activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Lysophosphatidic acid enhances healing of acute cutaneous wounds in the mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Latent transforming growth factor-beta: structural features and mechanisms of activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

The chemotactic response to PDGF-BB: evidence of a role for Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Smooth muscle differentiation in scleroderma fibroblastic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

6 June 2018

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

18 August 2018

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

18 August 2018

LPA1 receptor activation promotes renal interstitial fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

18 August 2018

Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

18 August 2018

Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

18 August 2018

Lysophosphatidic acid modulates the regenerative responses of human gingival fibroblasts and enhances the actions of platelet-derived growth factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

18 August 2018

Platelet-derived growth factor-BB and lysophosphatidic acid distinctly regulate hepatic myofibroblast migration through focal adhesion kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3086986

18 August 2018

Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidic acid induction of transforming growth factors alpha and beta: modulation of proliferation and differentiation in cultured human keratinocytes and mouse skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signalling properties of lysophosphatidic acid in primary human skin fibroblasts: role of pertussis toxin-sensitive GTP-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene profiling of scleroderma skin reveals robust signatures of disease that are imperfectly reflected in the transcript profiles of explanted fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/ART.30262

1 reference

Europe PubMed Central

10 October 2017

1 reference

Europe PubMed Central

10 October 2017

1 reference

Europe PubMed Central

10 October 2017

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