Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells (Q41813875)

12 October 2017

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells (English)

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12 October 2017

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12 October 2017

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Susan Lindquist

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12 October 2017

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Luke Whitesell

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12 October 2017

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Sandro Santagata

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12 October 2017

Irina Krykbaeva

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12 October 2017

Jianming Zhang

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12 October 2017

Qingsong Liu

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12 October 2017

Nathanael S Gray

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12 October 2017

30 June 2013

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630-637

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describes a project that uses

12 October 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/3774174

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nbt.2620

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cites work

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6 June 2018

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Comprehensive analysis of kinase inhibitor selectivity

6 June 2018

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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

6 June 2018

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In situ kinase profiling reveals functionally relevant properties of native kinases

6 June 2018

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6 June 2018

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Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies

6 June 2018

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Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia

6 June 2018

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Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site

6 June 2018

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Allosteric interactions between the myristate- and ATP-site of the Abl kinase

6 June 2018

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Trends in kinase selectivity: insights for target class-focused library screening

6 June 2018

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6 June 2018

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Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.

6 June 2018

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6 June 2018

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6 June 2018

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AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

6 June 2018

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A simple, flexible and efficient PCR-fusion/Gateway cloning procedure for gene fusion, site-directed mutagenesis, short sequence insertion and domain deletions and swaps.

6 June 2018

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An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell

6 June 2018

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The interplay of structural information and functional studies in kinase drug design: insights from BCR-Abl

6 June 2018

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Calorimetry and thermodynamics in drug design

6 June 2018

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High-throughput kinase profiling as a platform for drug discovery

6 June 2018

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A quantitative analysis of kinase inhibitor selectivity

6 June 2018

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6 June 2018

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The selectivity of protein kinase inhibitors: a further update

6 June 2018

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

6 June 2018

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An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms

6 June 2018

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TICdb: a collection of gene-mapped translocation breakpoints in cancer

6 June 2018

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Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

6 June 2018

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Structure of an Hsp90-Cdc37-Cdk4 complex.

6 June 2018

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Chaperoning steroid hormone action

6 June 2018

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ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages

6 June 2018

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High-throughput mapping of a dynamic signaling network in mammalian cells

6 June 2018

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A small molecule-kinase interaction map for clinical kinase inhibitors

6 June 2018

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6 June 2018

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Overriding imatinib resistance with a novel ABL kinase inhibitor

6 June 2018

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6 June 2018

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The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation

6 June 2018

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Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement.

6 June 2018

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Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25).

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3774174

Megakaryocytic differentiation of a leukemic cell line, MC3, by phorbol ester: induction of glycoprotein IIb/IIIa and effects on expression of IL-6, IL-6 receptor, mpl and GATA genes

6 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3774174

Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3774174

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3774174

Proteome-wide Analysis of Chaperonin-Dependent Protein Folding in Escherichia coli

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNBT.2620

Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23811600

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Stabilization of Proteins by Ligand Binding: Application to Drug Screening and Determination of Unfolding Energetics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23811600

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NBT.2620

1 reference

12 October 2017

1 reference

12 October 2017

1 reference