An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer (Q41820932)

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scientific article published on 3 December 2012

Language	Label	Description	Also known as
English	An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer	scientific article published on 3 December 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer (English)

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Christoph Garbers

1

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Joachim Grötzinger

8

object named as

Joachim Grötzinger

0 references

Samadhi Aparicio-Siegmund

3

object named as

Samadhi Aparicio-Siegmund

0 references

Stefan Rose-John

object named as

Stefan Rose-John

7

0 references

Christoph Hölscher

6

object named as

Christoph Hölscher

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

author name string

Björn Spudy

2

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Samadhi Aparicio-Siegmund

3

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Georg H Waetzig

4

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Jan Sommer

5

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Joachim Grötzinger

8

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Inken Lorenzen

9

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Jürgen Scheller

10

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Europe PubMed Central

PMC publication ID

12 October 2017

language of work or name

0 references

publication date

3 December 2012

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Europe PubMed Central

PMC publication ID

12 October 2017

number of pages

9

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

12 October 2017

288

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12 October 2017

6

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Europe PubMed Central

PMC publication ID

12 October 2017

4346-4354

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Plasticity and cross-talk of interleukin 6-type cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

A designer hyper interleukin 11 (H11) is a biologically active cytokine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

New directions in the basic and translational biology of interleukin-27.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Interleukin-30: a novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

ADAM17: a molecular switch to control inflammation and tissue regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

A role for IL-27p28 as an antagonist of gp130-mediated signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

No inhibition of IL-27 signaling by soluble gp130.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Soluble receptors for cytokines and growth factors: generation and biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

6 June 2018

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567685

18 August 2018

Processing of tumour necrosis factor-α precursor by metalloproteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.432955

21 January 2018

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209286

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.432955

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

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