Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling (Q27002391)

Crossref

language of work or name

1 reference

September 2011

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Journal of Clinical Investigation

published in

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volume

121

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page(s)

3375-83

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issue

9

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Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms

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Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease

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28 September 2017

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STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice.

28 September 2017

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Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules

28 September 2017

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Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP beta-deficient mice

28 September 2017

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The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

28 September 2017

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Soluble receptors for cytokines and growth factors: generation and biological function

28 September 2017

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Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo

28 September 2017

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The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome

28 September 2017

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In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment

28 September 2017

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Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling.

31 May 2018

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Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.

31 May 2018

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IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

31 May 2018

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31 May 2018

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Human soluble IL-6 receptor: its detection and enhanced release by HIV infection

31 May 2018

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High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo.

31 May 2018

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TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

31 May 2018

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Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

19 June 2018

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Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.

28 November 2018

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Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action

28 November 2018

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Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.

28 November 2018

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Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.

28 November 2018

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Oncostatin M deficiency leads to thymic hypoplasia, accumulation of apoptotic thymocytes and glomerulonephritis

28 November 2018

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STAT3 as a prognostic marker in human gastric cancer.

28 November 2018

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

28 November 2018

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Interleukin 27 attenuates collagen-induced arthritis.

28 November 2018

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Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

28 November 2018

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Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis.

28 November 2018

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Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

28 November 2018

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Interleukin-6 modulates production of T lymphocyte–derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis

28 November 2018

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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

28 November 2018

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Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling.

28 November 2018

1 reference

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Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163962

Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163962

Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163962

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163962

C-reactive protein: a physiological activator of interleukin 6 receptor shedding.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163962

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3163962

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3

28 November 2018

1 reference

12 December 2020

Actemra poised to launch IL-6 inhibitors

1 reference

12 December 2020

Understanding the IL-23-IL-17 immune pathway

1 reference

12 December 2020

Development of anti-TNF therapy for rheumatoid arthritis

1 reference

12 December 2020

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

1 reference

12 December 2020

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

1 reference

12 December 2020

Inhibiting IL-6 in human multiple myeloma

1 reference

12 December 2020

Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid

1 reference

12 December 2020

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

1 reference

12 December 2020

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6

1 reference

12 December 2020

Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

1 reference

12 December 2020

Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth

1 reference

12 December 2020

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

1 reference

12 December 2020

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1 reference

12 December 2020

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

1 reference

12 December 2020

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1 reference

12 December 2020

An anti-inflammatory role for interleukin-11 in established murine collagen-induced arthritis

1 reference

12 December 2020

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

1 reference

12 December 2020

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

1 reference

12 December 2020

IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6

1 reference

12 December 2020

RADIATE: more treatment options for patients with an inadequate response to tumor necrosis factor antagonists

1 reference

12 December 2020

STAT3 expression in gastric cancer indicates a poor prognosis

1 reference

12 December 2020

The JAK/STAT pathway in rheumatoid arthritis: Pathogenic or protective?

1 reference

12 December 2020

The Jak-STAT pathway in rheumatoid arthritis

1 reference

12 December 2020

The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin

1 reference

12 December 2020

Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells

1 reference

12 December 2020

Viral IL-6 Blocks Neutrophil Infiltration during Acute Inflammation

1 reference

12 December 2020