Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2 (Q41845063)

reason for preferred rank

13 October 2017

Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2 (English)

1 reference

https://api.crossref.org/works/10.1039/C0CC02969F

17 July 2024

Profiling small molecule inhibitors against helix-receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

17 July 2024

author name string

Ping Wang

3

1 reference

13 October 2017

Indraneel Ghosh

7

1 reference

13 October 2017

Jason R. Porter

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

17 July 2024

Mark R. Helmers

2

1 reference

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17 July 2024

Jennifer L. Furman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

17 July 2024

Stephen T. Joy

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

17 July 2024

Paramjit S. Arora

6

1 reference

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17 July 2024

language of work or name

English

0 references

publication date

20 September 2010

1 reference

full work available at URL

13 October 2017

https://europepmc.org/articles/pmc4576826?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

https://europepmc.org/articles/PMC4576826

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

https://europepmc.org/articles/PMC4576826?pdf=render

17 July 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

https://doi.org/10.1039/c0cc02969f

17 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20856941

http://pubs.rsc.org/en/content/articlepdf/2010/CC/C0CC02969F

17 July 2024

1 reference

https://api.crossref.org/works/10.1039/C0CC02969F

17 July 2024

published in

Chemical Communications

1 reference

13 October 2017

46

1 reference

13 October 2017

42

1 reference

13 October 2017

8020-8022

1 reference

Targeting the cancer kinome through polypharmacology

13 October 2017

1 reference

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The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions

6 June 2018

1 reference

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Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

6 June 2018

1 reference

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High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

6 June 2018

1 reference

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BCL-2 family antagonists for cancer therapy

6 June 2018

1 reference

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Contemporary strategies for the stabilization of peptides in the alpha-helical conformation

6 June 2018

1 reference

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

6 June 2018

1 reference

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

6 June 2018

1 reference

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Modulation of protein-protein interactions with small organic molecules

6 June 2018

1 reference

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Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Fluorescence polarization and anisotropy in high throughput screening: perspectives and primer

6 June 2018

1 reference

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Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments.

6 June 2018

1 reference

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Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

6 June 2018

1 reference

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Split ubiquitin as a sensor of protein interactions in vivo

6 June 2018

1 reference

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A general and rapid cell-free approach for the interrogation of protein-protein, protein-DNA, and protein-RNA interactions and their antagonists utilizing split-protein reporters

6 June 2018

1 reference

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Helical beta-peptide inhibitors of the p53-hDM2 interaction.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

18 August 2018

1 reference

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Inhibition of beta-amyloid fibrillization by directed evolution of a beta-sheet presenting miniature protein

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4576826

Miniature protein inhibitors of the p53-hDM2 interaction

3 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20856941

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20856941

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20856941

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Design and Evolution of a Miniature Bcl-2 Binding Protein

https://api.crossref.org/works/10.1039/C0CC02969F

3

1 reference

17 July 2024

Identifiers

DOI

10.1039/C0CC02969F

1 reference

13 October 2017

1 reference

13 October 2017

1 reference