Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury (Q41855554)

13 October 2017

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury (English)

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13 October 2017

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Sean M Davidson

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Mihaela M Mocanu

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object named as

Mihaela M Mocanu

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13 October 2017

Marta A Paiva

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13 October 2017

Zoe Rutter-Locher

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13 October 2017

Lino M Gonçalves

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13 October 2017

Luís A Providência

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13 October 2017

Derek M Yellon

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13 October 2017

18 March 2011

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American Journal of Physiology Heart and Circulatory Physiology

13 October 2017

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13 October 2017

300

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13 October 2017

6

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13 October 2017

H2123-34

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describes a project that uses

13 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3119096/fullTextXML

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cites work

Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction

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AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes

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AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress

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Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes

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AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase

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Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway

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Metformin prevents myocardial reperfusion injury by activating the adenosine receptor.

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AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells

5 June 2018

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Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure

5 June 2018

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AMPK: a key regulator of energy balance in the single cell and the whole organism.

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A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

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Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

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Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening

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Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

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Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

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Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion

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Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes

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Role of AMP-activated protein kinase in healthy and diseased hearts

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

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AMPK alterations in cardiac physiology and pathology: enemy or ally?

5 June 2018

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Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection

5 June 2018

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Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms

5 June 2018

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

5 June 2018

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Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury

5 June 2018

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AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

5 June 2018

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Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

5 June 2018

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The AMP-activated protein kinase cascade--a unifying system for energy control

5 June 2018

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Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury

5 June 2018

1 reference

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Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

5 June 2018

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The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity

5 June 2018

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Mitochondria: a target for myocardial protection.

5 June 2018

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Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes

5 June 2018

1 reference

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Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

5 June 2018

1 reference

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Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPK.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Preconditioning the diabetic heart: the importance of Akt phosphorylation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3119096

Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2010

Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits

21 January 2018

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12 December 2020

High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase

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12 December 2020

AMPK mediates autophagy during myocardial ischemia in vivo

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12 December 2020

Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb study. GUSTO IIb Investigators

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12 December 2020

10.1152/AJPHEART.00707.2010

Identifiers

DOI

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13 October 2017

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13 October 2017

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