TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells. (Q41865763)

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24 February 2020

title

TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells (English)

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24 February 2020

1 reference

1

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24 February 2020

author name string

Zizhen Wu

2

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24 February 2020

Nicolas Grillet

3

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24 February 2020

Linxuan Yan

4

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24 February 2020

Wei Xiong

5

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24 February 2020

Sarah Harkins-Perry

6

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24 February 2020

Ulrich Müller

7

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24 February 2020

language of work or name

English

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publication date

20 November 2014

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24 February 2020

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24 February 2020

volume

84

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24 February 2020

issue

5

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24 February 2020

page(s)

954-967

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New treatment options for hearing loss.

24 February 2020

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Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.

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Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

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Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells

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Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia

5 June 2018

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Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain

5 June 2018

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5 June 2018

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Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels

5 June 2018

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Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

5 June 2018

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5 June 2018

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The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish.

5 June 2018

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5 June 2018

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Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

1 reference

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5 June 2018

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Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle

5 June 2018

1 reference

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The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions

5 June 2018

1 reference

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Mutations in a novel gene, TMIE, are associated with hearing loss linked to the DFNB6 locus.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4258123

Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6

5 June 2018

1 reference

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Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function

5 June 2018

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Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations

5 June 2018

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The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses

5 June 2018

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Tip-link integrity and mechanical transduction in vertebrate hair cells

5 June 2018

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The actions of calcium on the mechano-electrical transducer current of turtle hair cells

5 June 2018

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Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome

5 June 2018

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Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells

18 August 2018

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Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes.

18 August 2018

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The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15

18 August 2018

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12 December 2020

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

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12 December 2020

Morphological correlates of mechanotransduction in acousticolateral hair cells

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12 December 2020

The effect of caged calcium release on the adaptation of the transduction current in chick hair cells

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12 December 2020

10.1016/J.NEURON.2014.10.041

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25467981%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25467981%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25467981

1 reference