Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes (Q41868973)

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scientific article published on 25 December 2008

Language	Label	Description	Also known as
English	Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes	scientific article published on 25 December 2008

Statements

scholarly article

1 reference

Europe PubMed Central

13 October 2017

Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes (English)

1 reference

Europe PubMed Central

13 October 2017

Leishmania amazonensis

object named as

Leishmania amazonensis

1 reference

based on heuristic

inferred from title

author name string

Aaron Ruhland

1

1 reference

Europe PubMed Central

13 October 2017

Peter E Kima

2

1 reference

Europe PubMed Central

13 October 2017

publication date

25 December 2008

1 reference

Europe PubMed Central

13 October 2017

Experimental Parasitology

1 reference

Europe PubMed Central

13 October 2017

122

1 reference

Europe PubMed Central

13 October 2017

1

1 reference

Europe PubMed Central

13 October 2017

28-36

1 reference

Europe PubMed Central

13 October 2017

FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Leishmania promastigotes activate PI3K/Akt signalling to confer host cell resistance to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

1 reference

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5 June 2018

Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy

1 reference

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5 June 2018

gC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway

1 reference

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5 June 2018

Quantitative real-time RT-PCR--a perspective.

1 reference

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5 June 2018

Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells

1 reference

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5 June 2018

TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii

1 reference

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Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?

1 reference

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5 June 2018

Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

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Phosphoinositide 3-kinase: diverse roles in immune cell activation

1 reference

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Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis

1 reference

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5 June 2018

Endogenous interleukin-12 is critical for controlling the late but not the early stage of Leishmania mexicana infection in C57BL/6 mice

1 reference

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5 June 2018

Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Regulation of interleukin-12 production in antigen-presenting cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Regulation of interleukin-12 production by G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa.

1 reference

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Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

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5 June 2018

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

1 reference

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5 June 2018

Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Adversarial relationship between the leishmania lipophosphoglycan and protein kinase C of host macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Interleukin-12: basic principles and clinical applications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Regulation of macrophage IL-12 synthesis by Leishmania phosphoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Host susceptibility factors to cutaneous leishmaniasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Interleukin-12 is indispensable for protective immunity against Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Regulation of interleukin-12 by complement receptor 3 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Selective suppression of interleukin-12 induction after macrophage receptor ligation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

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Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection

1 reference

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5 June 2018

The regulation of immunity to Leishmania major

1 reference

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5 June 2018

Regulation of interleukin 12 p40 expression through an NF-kappa B half-site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

5 June 2018

AKT can be activated in the nucleus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

18 August 2018

G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

18 August 2018

Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway

1 reference

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18 August 2018

Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

18 August 2018

Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

18 August 2018

JNK1 is required for T cell-mediated immunity against Leishmania major infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2669696

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Effective clearance of intracellularLeishmania majorin vivo requires Pten in macrophages

1 reference

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2 December 2018

p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19186178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K-mediated negative feedback regulation of IL-12 production in DCs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19186178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19186178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocytosis of Leishmania mexicana amastigotes by macrophages leads to a sustained suppression of IL-12 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/19186178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19186178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of IL-10 in promoting disease progression in leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19186178

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Silent infection of bone marrow-derived dendritic cells byLeishmania mexicana amastigotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19186178

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EXPPARA.2008.12.010

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

1 reference

Europe PubMed Central

13 October 2017

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