The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets. (Q41883110)

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13 January 2020

title

The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets (English)

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13 January 2020

5

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Andrea Graziani

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author name string

Gianni F Guidetti

1

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13 January 2020

Paolo Lova

2

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13 January 2020

Bruno Bernardi

3

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Francesca Campus

4

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13 January 2020

Cesare Balduini

7

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13 January 2020

Mauro Torti

8

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language of work or name

English

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publication date

28 August 2008

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Journal of Biological Chemistry

13 January 2020

published in

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volume

283

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issue

43

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page(s)

28795-28805

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describes a project that uses

13 January 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Diacylglycerol kinases: at the hub of cell signalling

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Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility.

5 June 2018

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The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3

5 June 2018

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Central role of the P2Y12 receptor in platelet activation

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Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton

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The P2Y(12) receptor induces platelet aggregation through weak activation of the alpha(IIb)beta(3) integrin--a phosphoinositide 3-kinase-dependent mechanism

5 June 2018

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Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs

5 June 2018

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Regulation of phosphoinositide-specific phospholipase C

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Identification of the platelet ADP receptor targeted by antithrombotic drugs

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Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs

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Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

5 June 2018

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Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic a

5 June 2018

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18 August 2018

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12 December 2020

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Identifiers

DOI

10.1074/JBC.M801588200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18755689%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

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13 January 2020

PubMed publication ID

18755689

1 reference