Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2. (Q41898534)

13 October 2017

Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2. (English)

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13 October 2017

H Porsch

1

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13 October 2017

B Bernert

2

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13 October 2017

M Mehić

3

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13 October 2017

A D Theocharis

4

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13 October 2017

C-H Heldin

5

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13 October 2017

P Heldin

6

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13 October 2017

language of work or name

English

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publication date

29 October 2012

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13 October 2017

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13 October 2017

32

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13 October 2017

37

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13 October 2017

4355-4365

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https://scigraph.springernature.com/pub.10.1038/onc.2012.475

13 October 2017

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cites work

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TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.

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A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs

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The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

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Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation

5 June 2018

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Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

5 June 2018

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Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

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Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

5 June 2018

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5 June 2018

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Intracellular hyaluronan: a new frontier for inflammation?

5 June 2018

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Hyaluronan: from extracellular glue to pericellular cue.

5 June 2018

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Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.

5 June 2018

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Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation

5 June 2018

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TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression.

5 June 2018

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Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells

5 June 2018

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Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors

5 June 2018

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5 June 2018

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Hyaluronan production increases the malignant properties of mesothelioma cells

5 June 2018

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Hyaluronan in morphogenesis

5 June 2018

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

5 June 2018

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Expression regulation of hyaluronan synthase in corneal endothelial cells.

5 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Expression of human hyaluronan synthases in response to external stimuli

5 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival

5 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties

5 June 2018

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Characterization and molecular evolution of a vertebrate hyaluronan synthase gene family

5 June 2018

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Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Functional cloning of the cDNA for a human hyaluronan synthase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Molecular identification of a putative human hyaluronan synthase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Expression cloning and molecular characterization of HAS protein, a eukaryotic hyaluronan synthase

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Intracellular hyaluronan in arterial smooth muscle cells: association with microtubules, RHAMM, and the mitotic spindle

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Differential effect of transforming growth factor beta (TGF-beta) on the genes encoding hyaluronan synthases and utilization of the p38 MAPK pathway in TGF-beta-induced hyaluronan synthase 1 activation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3778714

Expression of recombinant hyaluronan synthase (HAS) isoforms in CHO cells reduces cell migration and cell surface CD44

18 August 2018

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Crossref

https://api.crossref.org/works/10.1038%2FONC.2012.475

Irradiation-induced expression of hyaluronan (HA) synthase 2 and hyaluronidase 2 genes in rat lung tissue accompanies active turnover of HA and induction of types I and III collagen gene expression

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2012.475

Differential synthesis and binding of hyaluronan by human breast cancer cell lines

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23108409

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23108409

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2012.475

1 reference

Dimensions Publication ID

13 October 2017

0 references

1 reference

13 October 2017

1 reference