Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2 gene. (Q41902867)

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26 January 2020

title

Generation and Characterization of a genetic zebrafish model of SMA carrying the human SMN2 gene (English)

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26 January 2020

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2

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26 January 2020

author name string

Le T Hao

series ordinal

1

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26 January 2020

Christine E Beattie

series ordinal

3

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26 January 2020

publication date

28 March 2011

1 reference

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Molecular Neurodegeneration

26 January 2020

published in

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26 January 2020

volume

6

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26 January 2020

issue

1

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26 January 2020

page(s)

24

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https://scigraph.springernature.com/pub.10.1186/1750-1326-6-24

26 January 2020

exact match

0 references

cites work

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Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

5 June 2018

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A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease

5 June 2018

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RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN

5 June 2018

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5 June 2018

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Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice

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Regulation of SMN protein stability

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Embryonic motor axon development in the severe SMA mouse

5 June 2018

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Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy

5 June 2018

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Application of heat shock promoter in transgenic zebrafish

5 June 2018

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Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron

5 June 2018

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Simple and highly efficient BAC recombineering using galK selection

5 June 2018

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In vivo drug discovery in the zebrafish

5 June 2018

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Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.

5 June 2018

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A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy.

5 June 2018

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Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy

5 June 2018

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SMN gene duplication and the emergence of the SMN2 gene occurred in distinct hominids: SMN2 is unique to Homo sapiens.

5 June 2018

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Laser-induced gene expression in specific cells of transgenic zebrafish

5 June 2018

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The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

5 June 2018

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A mouse model for spinal muscular atrophy

5 June 2018

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A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2.

5 June 2018

1 reference

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A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080329

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080329

Identification of proximal spinal muscular atrophy carriers and patients by analysis of SMNT and SMNC gene copy number

5 June 2018

1 reference

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Identification and characterization of a spinal muscular atrophy-determining gene

5 June 2018

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Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy.

5 June 2018

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Transgenesis in fish: efficient selection of transgenic fish by co-injection with a fluorescent reporter construct.

18 August 2018

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18 August 2018

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Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2.

18 August 2018

1 reference

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SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21443782

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The SMN binding protein Gemin2 is not involved in motor axon outgrowth

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21443782

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1750-1326-6-24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21443782%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

26 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21443782%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

PubMed publication ID

21443782

1 reference