Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species (Q41930406)

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scientific article published on May 2006

Language	Label	Description	Also known as
English	Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species	scientific article published on May 2006

Statements

scholarly article

1 reference

Europe PubMed Central

14 October 2017

Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species (English)

1 reference

Europe PubMed Central

14 October 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

polycyclic aromatic hydrocarbons

1 reference

based on heuristic

inferred from title

Trevor M Penning

4

1 reference

Europe PubMed Central

14 October 2017

Andrea B. Troxel

object named as

Andrea B Troxel

2

0 references

author name string

Jong-Heum Park

1

1 reference

Europe PubMed Central

14 October 2017

Ronald G Harvey

3

1 reference

Europe PubMed Central

14 October 2017

publication date

1 May 2006

1 reference

Europe PubMed Central

14 October 2017

Chemical Research in Toxicology

1 reference

Europe PubMed Central

14 October 2017

19

1 reference

Europe PubMed Central

14 October 2017

5

1 reference

Europe PubMed Central

14 October 2017

719-728

1 reference

Europe PubMed Central

14 October 2017

Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2366214

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Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review

1 reference

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5 June 2018

Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling

1 reference

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5 June 2018

Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2366214

5 June 2018

Identification and characterization of novel stable deoxyguanosine and deoxyadenosine adducts of benzo[a]pyrene-7,8-quinone from reactions at physiological pH.

1 reference

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Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1).

1 reference

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Singlet oxygen induces oxidation of cellular DNA.

1 reference

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Repair and replication of oxidized DNA bases using modified oligodeoxyribonucleotides

1 reference

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Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues

1 reference

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Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts.

1 reference

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Oxidized, deaminated cytosines are a source of C --> T transitions in vivo

1 reference

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Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals

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Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions

1 reference

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Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

1 reference

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7,12-dimethylbenz[a]anthracene induces oxidative DNA modification in vivo.

1 reference

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Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

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Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

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Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on gamma-irradiation in aqueous solution.

1 reference

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Abasic sites from cytosine as termination signals for DNA synthesis

1 reference

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Production of oxidative DNA damage during the metabolic activation of benzo[a]pyrene in human mammary epithelial cells correlates with cell killing

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Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies

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Oxidized apurinic/apyrimidinic sites formed in DNA by oxidative mutagens

1 reference

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Formation of polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells during consumption of charcoal-broiled beef

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Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes

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Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization.

1 reference

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Association between cigarette smoking and urinary excretion of 1,N2-ethenoguanine measured by isotope dilution liquid chromatography-electrospray ionization/tandem mass spectrometry

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Analysis of M1G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry

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In vitro replication and repair of DNA containing a C2'-oxidized abasic site

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Hydroxychavicol modulates benzo[a]pyrene-induced genotoxicity through induction of dihydrodiol dehydrogenase

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Predominance of the 1,N2-propano 2'-deoxyguanosine adduct among 4-hydroxy-2-nonenal-induced DNA lesions

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Aldehydic DNA lesions in calf thymus DNA and HeLa S3 cells produced by bacterial quinone metabolites of fluoranthene and pyrene

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Synthesis of the o-quinones and other oxidized metabolites of polycyclic aromatic hydrocarbons implicated in carcinogenesis

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Oxidative DNA Damage Induced by Benz[a]anthracene Metabolites via Redox Cycles of Quinone and Unique Non-Quinone

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Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.

1 reference

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Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene

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Chromium(VI)-mediated DNA damage: oxidative pathways resulting in the formation of DNA breaks and abasic sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/16696575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA strand scission by polycyclic aromatic hydrocarbon o-quinones: role of reactive oxygen species, Cu(II)/Cu(I) redox cycling, and o-semiquinone anion radicals,

1 reference

https://pubmed.ncbi.nlm.nih.gov/16696575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022

1 reference

https://pubmed.ncbi.nlm.nih.gov/16696575

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/TX0600245

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

1 reference

Europe PubMed Central

14 October 2017

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